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Original ArticleOpen Access
Risk for Radical Hysterectomy Failure
Manusirivithaya S 
,
Charoeniam V ,
lsariyodom P ,
Pantusart A
,
Charoeniam V ,
lsariyodom P ,
Pantusart A During the period from July 1983 to December 1996, 685 patients who underwent radical
hysterectomy as their primary treatment for cervical cancer and had optimal follow-up _for at least
three years were analyzed. Fifty seven patients (8.3%) had pelvic nodes metastasis and received
postoperative whole pelvic radiation. Tumor recurrence was noted in 97 cases (14.2%). Nodal meta-
stasis is the most significant prognostic factor for tumor recurrence. Patients with nodal metastasis
had 42.1 per cent risk of recurrence compared to 11.6 per cent in those without nodal metastasis.
Furthermore; risk of recurrence significantly increased if more than 1 node was involved. Other
factors associated with a significantly higher risk of recurrence in multivariate analysis were tumor
histology and clinical stage. Patients with nonsquamous cell carcinoma and clinical stage Ila had
disease recurrence in 24.4 per cent and 30.3 per cent compared to only 11.7 per cent in squamous
and 13.3 per cent in stage lb. Tumor grade is the significant prognostic factor only in adenocar-
cinoma cell type but not in squamous cell type.
Key word : Cervical Cancer, Radical Hysterectomy, Recurrence
hysterectomy as their primary treatment for cervical cancer and had optimal follow-up _for at least
three years were analyzed. Fifty seven patients (8.3%) had pelvic nodes metastasis and received
postoperative whole pelvic radiation. Tumor recurrence was noted in 97 cases (14.2%). Nodal meta-
stasis is the most significant prognostic factor for tumor recurrence. Patients with nodal metastasis
had 42.1 per cent risk of recurrence compared to 11.6 per cent in those without nodal metastasis.
Furthermore; risk of recurrence significantly increased if more than 1 node was involved. Other
factors associated with a significantly higher risk of recurrence in multivariate analysis were tumor
histology and clinical stage. Patients with nonsquamous cell carcinoma and clinical stage Ila had
disease recurrence in 24.4 per cent and 30.3 per cent compared to only 11.7 per cent in squamous
and 13.3 per cent in stage lb. Tumor grade is the significant prognostic factor only in adenocar-
cinoma cell type but not in squamous cell type.
Key word : Cervical Cancer, Radical Hysterectomy, Recurrence
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