J Med Assoc Thai 2001; 84 (6):859

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Second Trimester Pregnancy Termination with 800 meg Vaginal Misoprostol
Pongsatha S Mail, Tongsong T

SAIPIN PONGSATHA, M.D.*,
THEERA TONGSONG, M.D.*
Objective
: To demonstrate the efficacy of 800 microgram vaginal rnisoprostol tablet for
second trimester pregnancy termination.
Design
: Prospective descriptive study.
Setting
: Maharaj Nakom Chiang Mai Hospital, Department of Obstetrics and Gyneco-
logy, Faculty of Medicine, Chiang Mai University.
Subject
: Pregnant women meeting the inclusion criteria including (1) singleton pregnancy
with live fetus, (2) gestational age of 14-28 weeks, (3) indication for therapeutic termination, (4)
closed and uneffaced cervix, (5) absence of uterine contraction and leakage of amniotic fluid, (6)
no previous classical uterine scar, (7) no contraindication for rnisoprostol such as hypersensitivity.
Intervention
: 800 microgram rnisoprostol tablet intravagina every 12 hours.
Main outcome measures
: Mean induction delivery time, mean abortion time, maternal
side effects.
Results
: The mean induction delivery time was 21.38
เธ‘
13.68 hours, mean abortion time
was 21.56
เธ‘
13.68 hours. Diarrhea was the most common side effect occuring in 40 per cent of
patients.
Conclusions
: 800 meg vaginal misoprostol every 12 hours is effective but if we want
high efficacy along with fewer side effects, lower dose and interval should
be
further studied.
Key word:
Misoprostol, Second Trimester Pregnancy Termination, Induction-Delivery Time, Mean
Abortion Time

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