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Original ArticleOpen Access
Assessment of Perindopril's Efficacy on Arterial Distensibility in Mild to Moderate Hypertension
Collaborative C 
Objective : Angiotensin Converting Enzyme Inhibitors (ACEis) have been clearly proven
to be effective in blood pressure control and haemodynamic control in heart failure patients. More-
over, there is evidence that ACEis, both in animal models and in humans, also possess the ability
to reduce remodeling in cardiovascular structures. Therefore, the reduction of the occurrence of
arterial stiffness, leading to an increase in distensibility, is also anticipated.
Method : Other than physically measuring arterial wall, the assessment of Pulse Wave
Velocity (PWV) is also a widely used index of arterial distensibility, which deteriorates through the
course of remodeling. To determine the efficacy of a particular ACEI, perindopril, in increasing
arterial distensibility, thus reducing PWV, a 6-month multi-center study was conducted in 146 patients
with mild to moderate hypertension. The study population consisted of 70 men and 76 women, aged
56.36 (SD 9.4, range 28-73) years. 73 patients were newly diagnosed, 65 were treated patients
but the blood pressure was not controlled, and 8 were treated patients with their blood pressure
controlled but with adverse effects in need of switching treatment regimens.
Results : Mean blood pressure at the beginning of the study was 164.25/97.49 mmHg and
11.71 m/s (SD 2.29 range 7.35-20.12 m/s) in mean PWV. Perindopril was prescribed tritrating
from 4 mg/day to 8 mg/day and adding a diuretic. 106 patients completed the study with 76.4 per
cent of patients having their blood pressure controlled (Mean Blood pressure 138.6/85.18 mmHg,
SD 11.34 and 7.10 Range 110-170/70-110 mmHg) (p
to be effective in blood pressure control and haemodynamic control in heart failure patients. More-
over, there is evidence that ACEis, both in animal models and in humans, also possess the ability
to reduce remodeling in cardiovascular structures. Therefore, the reduction of the occurrence of
arterial stiffness, leading to an increase in distensibility, is also anticipated.
Method : Other than physically measuring arterial wall, the assessment of Pulse Wave
Velocity (PWV) is also a widely used index of arterial distensibility, which deteriorates through the
course of remodeling. To determine the efficacy of a particular ACEI, perindopril, in increasing
arterial distensibility, thus reducing PWV, a 6-month multi-center study was conducted in 146 patients
with mild to moderate hypertension. The study population consisted of 70 men and 76 women, aged
56.36 (SD 9.4, range 28-73) years. 73 patients were newly diagnosed, 65 were treated patients
but the blood pressure was not controlled, and 8 were treated patients with their blood pressure
controlled but with adverse effects in need of switching treatment regimens.
Results : Mean blood pressure at the beginning of the study was 164.25/97.49 mmHg and
11.71 m/s (SD 2.29 range 7.35-20.12 m/s) in mean PWV. Perindopril was prescribed tritrating
from 4 mg/day to 8 mg/day and adding a diuretic. 106 patients completed the study with 76.4 per
cent of patients having their blood pressure controlled (Mean Blood pressure 138.6/85.18 mmHg,
SD 11.34 and 7.10 Range 110-170/70-110 mmHg) (p
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