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Original ArticleOpen Access
Effect and Safety of 17 8-Estradiol Vaginal Tablet in Postmenopausal Women with Urogenital Symptoms
Manonai J 
,
Theppisai U ,
Chittacharoen A
,
Theppisai U ,
Chittacharoen A JITTIMA MANON AI, M.D.*,
URUSA THEPPISAI, M.D.*,
APICHART CHITTACHAROEN, M.D.*
Objective : To evaluate the effects of a 17
~-estradiol
vaginal tablet on urogenital symp-
toms, vaginal pH, vaginal cytology, endometrial thickness, and plasma estradiol level in postmeno-
pausal women with urogenital symptoms.
Method : Twenty-seven postmenopausal women with urogenital symptoms received 25
!lg of a 17
~-estradiol
tablet intravaginally daily for the first 2 weeks, followed by 10 weeks of
twice a week dosage. The results of urogenital symptoms, vaginal pH, vaginal cytology, endometrial
thickness, and plasma estradiol level were analysed.
Results : The urogenital symptoms improved significantly in all women. The mean vagi-
nal pH was significantly decreased. The vaginal cytology showed estrogenic effect on the karyopy-
knotic index and the maturation value. There was no significant difference in endometrial thick-
ness and level of plasma estradiol before and after treatment. There was one case of vaginal bleed-
ing from endometrial proliferation.
Conclusion : Local vaginal treatment of 17
~-estradiol
(25 !lg) had a positive effect on the
urogenital symptoms, vaginal pH, and vaginal cytology. No elevation of plasma estradiol level was
detected after treatment.
Key word : Estradiol Vaginal Tablet, Urogenital Symptoms, Postmenopausal Women
URUSA THEPPISAI, M.D.*,
APICHART CHITTACHAROEN, M.D.*
Objective : To evaluate the effects of a 17
~-estradiol
vaginal tablet on urogenital symp-
toms, vaginal pH, vaginal cytology, endometrial thickness, and plasma estradiol level in postmeno-
pausal women with urogenital symptoms.
Method : Twenty-seven postmenopausal women with urogenital symptoms received 25
!lg of a 17
~-estradiol
tablet intravaginally daily for the first 2 weeks, followed by 10 weeks of
twice a week dosage. The results of urogenital symptoms, vaginal pH, vaginal cytology, endometrial
thickness, and plasma estradiol level were analysed.
Results : The urogenital symptoms improved significantly in all women. The mean vagi-
nal pH was significantly decreased. The vaginal cytology showed estrogenic effect on the karyopy-
knotic index and the maturation value. There was no significant difference in endometrial thick-
ness and level of plasma estradiol before and after treatment. There was one case of vaginal bleed-
ing from endometrial proliferation.
Conclusion : Local vaginal treatment of 17
~-estradiol
(25 !lg) had a positive effect on the
urogenital symptoms, vaginal pH, and vaginal cytology. No elevation of plasma estradiol level was
detected after treatment.
Key word : Estradiol Vaginal Tablet, Urogenital Symptoms, Postmenopausal Women
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