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Original ArticleOpen Access
A Comparison Between 50 meg Oral Misoprostol Every 4 Hours and 6 Hours for Labor Induction : A Prospective Randomized Controlled Trial
Pongsatha S 
,
song TT ,
Somsak T
,
song TT ,
Somsak T SAIPIN PONGSATHA, M.D.*,
THEERA TONGSONG, M.D.*,
THAPANAT SOMSAK, M.D.*
Objective : To compare the effectiveness and safety between 50 meg oral misoprostol
every 4 hours and 6 hours for labor induction.
Design : A prospective randomized controlled trial.
Setting : Department of Obstetrics
&
Gynecology, Faculty of Medicine, Chiang Mai
University, Chiang Mai, Thailand.
Subjects : Eighty nine pregnant women of at least 34 weeks' gestation with indications
for labor induction in the condition of unfavourable cervix (Bishop score
~
4) and no contraindi-
cation to prostaglandin therapy.
Interventions : All pregnant women were randomized to receive either 50 meg misoprostol
orally every 4 hours or 6 hours.
Main Outcome Measures : Treatment interval from induction to vaginal delivery, maternal
and neonatal complication.
Results : The mean treatment intervals from induction to vaginal delivery were 22.10
เธ‘
18.49 hours and 20.91
เธ‘
11.98 hours in the misoprostol group every 4 hours and 6 hours, respec-
tively. The treatment intervals between the two groups were not statistically significant. There was
also no significant difference between both groups with regard to maternal and neonatal compli-
cations.
Conclusion : The effectiveness in terms of treatment interval from induction to vaginal
delivery were comparable between the two groups, but administration of misoprostol every 6 hours
was found to have a slightly shorter interval, although it did not reach statistical significance. No
serious maternal and neonatal complication was demonstrated in both groups. Either regimen in
this study can be an alternative for labor induction.
Key word : Misoprostol, Labor, Unfavorable Cervix
THEERA TONGSONG, M.D.*,
THAPANAT SOMSAK, M.D.*
Objective : To compare the effectiveness and safety between 50 meg oral misoprostol
every 4 hours and 6 hours for labor induction.
Design : A prospective randomized controlled trial.
Setting : Department of Obstetrics
&
Gynecology, Faculty of Medicine, Chiang Mai
University, Chiang Mai, Thailand.
Subjects : Eighty nine pregnant women of at least 34 weeks' gestation with indications
for labor induction in the condition of unfavourable cervix (Bishop score
~
4) and no contraindi-
cation to prostaglandin therapy.
Interventions : All pregnant women were randomized to receive either 50 meg misoprostol
orally every 4 hours or 6 hours.
Main Outcome Measures : Treatment interval from induction to vaginal delivery, maternal
and neonatal complication.
Results : The mean treatment intervals from induction to vaginal delivery were 22.10
เธ‘
18.49 hours and 20.91
เธ‘
11.98 hours in the misoprostol group every 4 hours and 6 hours, respec-
tively. The treatment intervals between the two groups were not statistically significant. There was
also no significant difference between both groups with regard to maternal and neonatal compli-
cations.
Conclusion : The effectiveness in terms of treatment interval from induction to vaginal
delivery were comparable between the two groups, but administration of misoprostol every 6 hours
was found to have a slightly shorter interval, although it did not reach statistical significance. No
serious maternal and neonatal complication was demonstrated in both groups. Either regimen in
this study can be an alternative for labor induction.
Key word : Misoprostol, Labor, Unfavorable Cervix
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