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Original ArticleOpen Access
Spontaneous Bacterial Peritonitis, Causes and Antibiotic Usage in Srinagarind Hospital
Lolekha P 
,
Chunlertrith K
,
Chunlertrith K Spontaneous bacterial peritonitis (SBP) is a common and often fatal complication occurr-
ing in cirrhotic patients with ascites.
It
is defined as an infection of the ascitic fluid in the absence
of any obvious intra-abdominal source. This study was a descriptive retrospective study that exa-
mined signs and symptoms of SBP, prevalence, result of the culture and antibiotic susceptibility
of the organisms and outcome of antibiotic treatment, especially to ampicillin-aminoglycoside
Data were collected from inpatient medical records at Srinagarind Hospital between 1993 and 1997.
Forty-four patients with 54 episodes of SBP were included in this study. The results revealed that
SBP commonly occurred in cirrhotic patients. Presenting symptoms of SBP were fever, abdominal
pain and abdominal distension, respectively. Signs of SBP were ascites and rebound abdominal
tenderness. Forty-three per cent of ascitic fluid cultures were positive for bacteria
E. coli
(30.4% ),
Streptococcus
spp (26.1%) and
Klebsiella
spp (13.0%) were the most common causes of SBP which
were similar to other studies. Ampicillin plus an aminoglycoside were mostly often used in this
study; in only 15.8 per cent of patients did the antibiotics need to be changed. Mortality rate in this
group was not increased after antibiotic was changed.
Key word
: Spontaneous Bacterial Peritonitis,
E.coli, Streptococcus
spp, Antibiotic Regimen
ing in cirrhotic patients with ascites.
It
is defined as an infection of the ascitic fluid in the absence
of any obvious intra-abdominal source. This study was a descriptive retrospective study that exa-
mined signs and symptoms of SBP, prevalence, result of the culture and antibiotic susceptibility
of the organisms and outcome of antibiotic treatment, especially to ampicillin-aminoglycoside
Data were collected from inpatient medical records at Srinagarind Hospital between 1993 and 1997.
Forty-four patients with 54 episodes of SBP were included in this study. The results revealed that
SBP commonly occurred in cirrhotic patients. Presenting symptoms of SBP were fever, abdominal
pain and abdominal distension, respectively. Signs of SBP were ascites and rebound abdominal
tenderness. Forty-three per cent of ascitic fluid cultures were positive for bacteria
E. coli
(30.4% ),
Streptococcus
spp (26.1%) and
Klebsiella
spp (13.0%) were the most common causes of SBP which
were similar to other studies. Ampicillin plus an aminoglycoside were mostly often used in this
study; in only 15.8 per cent of patients did the antibiotics need to be changed. Mortality rate in this
group was not increased after antibiotic was changed.
Key word
: Spontaneous Bacterial Peritonitis,
E.coli, Streptococcus
spp, Antibiotic Regimen
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