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Original ArticleOpen Access
Corneal Abnormalities in Diabetes
Siribunkum J 
,
Kosrirukvongs P ,
Singalavanija A
,
Kosrirukvongs P ,
Singalavanija A JANPEN SIRIBUNKUM, M.D.*,
PANIDA KOSRIRUKVONGS, M.D.**,
API CHART SIN GALA V ANUA, M.D.**
Objective
: To compare corneal thickness and endothelial morphology in patients with dia-
betes mellitus and age-matched normal subjects, and to determine whether the duration of diabetes
mellitus, severity of diabetic retinopathy, and glycemic control are correlated with these measure-
ments.
Design
: Single center, case-control study.
Participants
: Sixty eyes of thirty diabetic patients and sixty eyes of thirty healthy non-
diabetic subjects were studied.
Intervention
: Corneal thickness was measured by ultrasonic pachymeter. Corneal endo-
thelial morphology was examined with a contact specular microscope.
Main Outcome Measures
: Corneal endothelial cell density, mean cell area, coefficient
of variation, percentages of hexagonal cells, and corneal thickness were measured.
Results
: There was statistically significant increased corneal endothelial cell density and
decreased mean endothelial cell area in the diabetic patients. The diabetic corneas had an increased
coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cell
and an increased corneal thickness compared with the control subjects, but these differences were
not statistically significant. The duration of diabetes mellitus was significantly correlated with pleo-
morphism, polymegathism and corneal thickness. Severity of diabetic retinopathy was correlated
with endothelial cell density, but these correlations were low. The corneal changes were not cor-
related with glycemic control.
Conclusions
: The diabetic corneas tended to be thicker and had more pleomorphism and
polymegathism, though this was not statistically significant. Duration of diabetes mellitus correlated
1076
PANIDA KOSRIRUKVONGS, M.D.**,
API CHART SIN GALA V ANUA, M.D.**
Objective
: To compare corneal thickness and endothelial morphology in patients with dia-
betes mellitus and age-matched normal subjects, and to determine whether the duration of diabetes
mellitus, severity of diabetic retinopathy, and glycemic control are correlated with these measure-
ments.
Design
: Single center, case-control study.
Participants
: Sixty eyes of thirty diabetic patients and sixty eyes of thirty healthy non-
diabetic subjects were studied.
Intervention
: Corneal thickness was measured by ultrasonic pachymeter. Corneal endo-
thelial morphology was examined with a contact specular microscope.
Main Outcome Measures
: Corneal endothelial cell density, mean cell area, coefficient
of variation, percentages of hexagonal cells, and corneal thickness were measured.
Results
: There was statistically significant increased corneal endothelial cell density and
decreased mean endothelial cell area in the diabetic patients. The diabetic corneas had an increased
coefficient of variation of endothelial cell area, a decreased percentage of hexagonal endothelial cell
and an increased corneal thickness compared with the control subjects, but these differences were
not statistically significant. The duration of diabetes mellitus was significantly correlated with pleo-
morphism, polymegathism and corneal thickness. Severity of diabetic retinopathy was correlated
with endothelial cell density, but these correlations were low. The corneal changes were not cor-
related with glycemic control.
Conclusions
: The diabetic corneas tended to be thicker and had more pleomorphism and
polymegathism, though this was not statistically significant. Duration of diabetes mellitus correlated
1076
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