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Original ArticleOpen Access
Lactose Intolerance and Intestinal Villi Morphology in Thai People
ThongNgam D 
,
Tangkijvanich P ,
Suwangool P ,
Vivatvekin B ,
Prempracha J ,
Sriratanabun A
,
Tangkijvanich P ,
Suwangool P ,
Vivatvekin B ,
Prempracha J ,
Sriratanabun A PIS IT TANGKUV ANICH, M.D.**,
BUDSABA VIVATVEKIN, M.D.****,
AMNART SRIRATANABUN, M.D.*****
Objective : To study the relationship of lactose intolerance and intestinal
villi
morpho-
logy
in Thai
people.
Material and Method : Subjects for
this
study were patients
with
functional dyspepsia
who had no history of milk allergy and underwent gastroduodenoscopy. Two mucosal biopsy
specimens were taken from beyond the distal end of the second part of the duodenum. The speci-
mens were carefully orientated and were graded according to the following scheme: group I :
finger shaped villi; group II : mixed finger and leaf shaped villi; group III : clubbing or blunting
shaped villi. All subjects were tested for lactose malabsorption by breath hydrogen analysis after
consuming 50 gram lactose. Breath hydrogen concentration was analyzed
in
samples collected
intermittently by end-expiratory technique. A rise in breath hydrogen concentration of 20 PPM
over baseline was considered evidence of lactose malabsorption.
Results : The twenty-five subjects were twenty females (80.0%) and five males (20.0%)
who ranged
in
age from 18 to 53 years (mean 31 เธ‘8.29). Sixteen subjects belonged to the finger
shaped
villi
group (64.0% ), five to the
mixed
finger and leaf shaped
villi
group (20.0%) and four
to the clubbing or blunting shaped villi group ( 16.0% ). Results of breath hydrogen excretion test
identified the prevalence of lactose intolerance
in
68 per cent of the subjects: 15116 (93.75%)
of group I ; 1/5 (20.0%) of group II and l/4 (25%) of group III respectively (P
BUDSABA VIVATVEKIN, M.D.****,
AMNART SRIRATANABUN, M.D.*****
Objective : To study the relationship of lactose intolerance and intestinal
villi
morpho-
logy
in Thai
people.
Material and Method : Subjects for
this
study were patients
with
functional dyspepsia
who had no history of milk allergy and underwent gastroduodenoscopy. Two mucosal biopsy
specimens were taken from beyond the distal end of the second part of the duodenum. The speci-
mens were carefully orientated and were graded according to the following scheme: group I :
finger shaped villi; group II : mixed finger and leaf shaped villi; group III : clubbing or blunting
shaped villi. All subjects were tested for lactose malabsorption by breath hydrogen analysis after
consuming 50 gram lactose. Breath hydrogen concentration was analyzed
in
samples collected
intermittently by end-expiratory technique. A rise in breath hydrogen concentration of 20 PPM
over baseline was considered evidence of lactose malabsorption.
Results : The twenty-five subjects were twenty females (80.0%) and five males (20.0%)
who ranged
in
age from 18 to 53 years (mean 31 เธ‘8.29). Sixteen subjects belonged to the finger
shaped
villi
group (64.0% ), five to the
mixed
finger and leaf shaped
villi
group (20.0%) and four
to the clubbing or blunting shaped villi group ( 16.0% ). Results of breath hydrogen excretion test
identified the prevalence of lactose intolerance
in
68 per cent of the subjects: 15116 (93.75%)
of group I ; 1/5 (20.0%) of group II and l/4 (25%) of group III respectively (P
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