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Original ArticleOpen Access
Serological Study of Toxoplas1111l gondii in Kidney Recipients
Sukthana Y 
,
Damrongkitchaipom S ,
Chintana T ,
Lekkla A
,
Damrongkitchaipom S ,
Chintana T ,
Lekkla A Toxoplasma gondii
lgG antibodies were determined in 200 kidney recipients by the Sabin-
Felmand dye test. Twenty-two (11%) cases were positive for antibody detection. There was a statis-
tically significant difference in the history of taking under-cooked meat, between the number of
sero-positive cases and that of sero-negative subjects (63.6%
vs
28.8%, p
=
0.02). No such signi-
ficant difference was evident regarding cat ownership (13.6%
vs
22.0%, p
=
0.3).
Sixteen (72.6%) of the 22 subjects with positive
T.gondii
antibody had undergone kidney
transplantation less than one year ago during which a high dose of immunosuppressive drugs were
prescribed. The remaining six (27.3%) cases had had transplantation more than one year ago and
were on a lower dosage of immunosuprresants. Toxoplasma reactivation seemed to be higher in the
former group, which should thus be closely followed-up. Preventive chemoprophylaxis should be
considered if there is any indication of toxoplasma reactivation.
Since there have been occasional reports of donor-to-host transmission of toxoplasmosis
in kidney transplant recipients, serological screening of toxoplasma antibody in kidney donors is
advisable. Potential donors with positive toxoplasma antibody should be rejected; but if that is
unavoidable, 6-week prophylactic treatment of primary infection in kidney recipients should be
administered.
Key word :
Toxoplasma Gondii
Antibody, Kidney Recipients
lgG antibodies were determined in 200 kidney recipients by the Sabin-
Felmand dye test. Twenty-two (11%) cases were positive for antibody detection. There was a statis-
tically significant difference in the history of taking under-cooked meat, between the number of
sero-positive cases and that of sero-negative subjects (63.6%
vs
28.8%, p
=
0.02). No such signi-
ficant difference was evident regarding cat ownership (13.6%
vs
22.0%, p
=
0.3).
Sixteen (72.6%) of the 22 subjects with positive
T.gondii
antibody had undergone kidney
transplantation less than one year ago during which a high dose of immunosuppressive drugs were
prescribed. The remaining six (27.3%) cases had had transplantation more than one year ago and
were on a lower dosage of immunosuprresants. Toxoplasma reactivation seemed to be higher in the
former group, which should thus be closely followed-up. Preventive chemoprophylaxis should be
considered if there is any indication of toxoplasma reactivation.
Since there have been occasional reports of donor-to-host transmission of toxoplasmosis
in kidney transplant recipients, serological screening of toxoplasma antibody in kidney donors is
advisable. Potential donors with positive toxoplasma antibody should be rejected; but if that is
unavoidable, 6-week prophylactic treatment of primary infection in kidney recipients should be
administered.
Key word :
Toxoplasma Gondii
Antibody, Kidney Recipients
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