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Original ArticleOpen Access
Uracil with Ftorafur and Low Dose Oral Folinic Acid in Advanced Colorectal Cancer
ChakrapeeSirisuk S 
,
Srimuninnimit V ,
Sinlarat P ,
Vathanophas V ,
Lohsiriwat D ,
ArchYaemsuan P ,
LenAkayamanee N ,
Boonnuch W ,
Nimmanwudipong T
,
Srimuninnimit V ,
Sinlarat P ,
Vathanophas V ,
Lohsiriwat D ,
ArchYaemsuan P ,
LenAkayamanee N ,
Boonnuch W ,
Nimmanwudipong T VICHIEN SRIMUNINNIMIT, M.D.*,
VITHYA VATHANOPHAS,M.D.**,
PAIROACH ARCH-YAEMSUAN, M.D.**,
WIROON BOONNUCH, M.D.**,
Background : Low dose oral Folinic acid was used together with uracil with ftorafur
(UFf) producing some response with low toxicity in advanced colorectal cancer. However, the 28
day regimen produced 20 per cent severe (grade III, IV) diarrhea. This study required 21 days' treat-
ment to evaluate the response rate and toxicity in advanced colorectal cancer.
Method : UFf 300 mg/m
2
/day together with oral Folinic acid 7.5 mg/dose for 21 days
with 7 days rest were required to treat 28 cases of recurrent or metastatic colorectal cancer.
Results : Partial response was seen in 13.6 per cent of 22 evaluable cases and minimal res-
ponse seen in 18.2 per cent. The majority (77%) of these patients had previously been treated with
5-tluorouracil (5-FU). These results are comparable to other studies. Toxicity was low with 3.3
per cent grade III, IV diarrhea.
Conclusion : This regimen produced some activity in metastatic colorectal cancer with low
toxicity.
Key word : UFf, Folinic Acid, Colorectal Cancer
VITHYA VATHANOPHAS,M.D.**,
PAIROACH ARCH-YAEMSUAN, M.D.**,
WIROON BOONNUCH, M.D.**,
Background : Low dose oral Folinic acid was used together with uracil with ftorafur
(UFf) producing some response with low toxicity in advanced colorectal cancer. However, the 28
day regimen produced 20 per cent severe (grade III, IV) diarrhea. This study required 21 days' treat-
ment to evaluate the response rate and toxicity in advanced colorectal cancer.
Method : UFf 300 mg/m
2
/day together with oral Folinic acid 7.5 mg/dose for 21 days
with 7 days rest were required to treat 28 cases of recurrent or metastatic colorectal cancer.
Results : Partial response was seen in 13.6 per cent of 22 evaluable cases and minimal res-
ponse seen in 18.2 per cent. The majority (77%) of these patients had previously been treated with
5-tluorouracil (5-FU). These results are comparable to other studies. Toxicity was low with 3.3
per cent grade III, IV diarrhea.
Conclusion : This regimen produced some activity in metastatic colorectal cancer with low
toxicity.
Key word : UFf, Folinic Acid, Colorectal Cancer
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