J Med Assoc Thai 2001; 84 (8):1199

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The First World Report of Botulinum A Toxin Injection for Status Migrainosus
Poungvarin N Mail

The author reports the first ever documented publication in the world concerning the
use of botulinum toxin A (BTX-A) injection for status migrainosus. A 58-year old man had been
suffering from migraine without aura for 20 years. This last attack (a very severe throbbing
headache) started over the left side of his head and he had tried several medications (paracetamol,
aspirin, ergotamine, mefenamic acid, and diazepam) during the attack to no vail. Physical
examination revealed an acutely ill patient with an agonizing pain condition. General and neu-
rological examinations were normal. BTX-A solution was then injected into the Fung Chou
point (classical Chinese acupuncture point for migraine) in the total amount of 25 international
unit. Dramatic response was observed within I hour of injection and status migrainosus was abort
within 10 hours. He was headache-free and had no further attack of migraine for another 2
months.
Key word
: Botulinum A Toxin, Status Migrainosus

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