Views: 1,529 | Downloads:
33
| Responses: 0
| XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Original ArticleOpen Access
Invasive Pneumococcal Infection and Drug-Resistant Streptococcus pneumoniae in Thai Children
Pancharoen C 
,
Chongthaleong A ,
Reinprayoon S ,
Thisyakom U
,
Chongthaleong A ,
Reinprayoon S ,
Thisyakom U Sixty-eight children with systemic
Streptococcus pneumoniae
infection were identified by
hospital chart review between 1986-1997. The age distribution varied from 2 days to 15 years, with
a mean age of 3.3 years. There were 35 boys and 33 girls. Four clinical entities included 30 cases
of meningitis, 20 cases of pneumonia, 10 cases of peritonitis and 8 cases of septicemia/bacteremia.
Forty patients (58.8%) had underlying diseases. Seventeen patients (25.0%) developed early com-
plications and the mortality rate was 8.8 per cent. The percentage of susceptible isolates to peni-
cillin, chloramphenicol, cefotaxime/ ceftriaxone, ciprofloxacin, irnipenem and vancomycin were
69.6, 91.3, 100.0, 87.2, 100.0 and 97.1 per cent, respectively. There were six cases of drug-resis-
tant S.
pneumoniae
(DRSP) infection; 3 cases of meningitis, one case of pneumonia, one case of
infective endocarditis and one case of purpura fulminans. Our data indicate that S.
pneumoniae
infection is relatively serious and life-threatening. There is a trend of increasing prevalence of
invasive pneumococcal and DRSP infections.
Key word : Pneumococcus, S.
pneumoniae,
DRSP, children
Streptococcus pneumoniae
infection were identified by
hospital chart review between 1986-1997. The age distribution varied from 2 days to 15 years, with
a mean age of 3.3 years. There were 35 boys and 33 girls. Four clinical entities included 30 cases
of meningitis, 20 cases of pneumonia, 10 cases of peritonitis and 8 cases of septicemia/bacteremia.
Forty patients (58.8%) had underlying diseases. Seventeen patients (25.0%) developed early com-
plications and the mortality rate was 8.8 per cent. The percentage of susceptible isolates to peni-
cillin, chloramphenicol, cefotaxime/ ceftriaxone, ciprofloxacin, irnipenem and vancomycin were
69.6, 91.3, 100.0, 87.2, 100.0 and 97.1 per cent, respectively. There were six cases of drug-resis-
tant S.
pneumoniae
(DRSP) infection; 3 cases of meningitis, one case of pneumonia, one case of
infective endocarditis and one case of purpura fulminans. Our data indicate that S.
pneumoniae
infection is relatively serious and life-threatening. There is a trend of increasing prevalence of
invasive pneumococcal and DRSP infections.
Key word : Pneumococcus, S.
pneumoniae,
DRSP, children
Download:
PDF