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Case ReportOpen Access
Microvillus Inclusion Disease as a Cause of Severe Protracted Diarrhea in Infants
Ukarapol N 
,
Chotinaruemol S ,
Lertprasertsuk N ,
Wongsawasdi L
,
Chotinaruemol S ,
Lertprasertsuk N ,
Wongsawasdi L There are many etiologies responsible for severe intractable diarrhea in infancy, for in-
stance, autoimmune enteropathy, microvillus inclusion disease, tufting enteropathy, food allergy,
post-enteritis syndrome, chronic intestinal pseudo-obstruction, Hirschsprung's disease, intestinal
lymphangiectasia, congenital sodium or chloride diarrhea, and congenital enzymatic deficiency. This
article reports a case of microvillus inclusion disease in a Thai patient. He presented with severe
intractable watery diarrhea with persistent metabolic acidosis. After extensive investigation, the
diagnosis of microvillus inclusion disease was made, based on the ultrastructural findings of
microvillus inclusions in the cytoplasm of the enterocyte on electron microscopic study. Various
treatments were introduced to the patient without clinical improvement, including cholestyramine,
metronidazole, probiotics, and octreotide. He was dependent on total parenteral nutrition and sub-
sequently died from TPN-related complications. Even though it is a rare disease, it should be con-
sidered if an infant has chronic secretory diarrhea.
Key word : Microvillus Inclusion Disease, Chronic Secretory Diarrhea, Diagnosis, Ultrastructure
Pathology
stance, autoimmune enteropathy, microvillus inclusion disease, tufting enteropathy, food allergy,
post-enteritis syndrome, chronic intestinal pseudo-obstruction, Hirschsprung's disease, intestinal
lymphangiectasia, congenital sodium or chloride diarrhea, and congenital enzymatic deficiency. This
article reports a case of microvillus inclusion disease in a Thai patient. He presented with severe
intractable watery diarrhea with persistent metabolic acidosis. After extensive investigation, the
diagnosis of microvillus inclusion disease was made, based on the ultrastructural findings of
microvillus inclusions in the cytoplasm of the enterocyte on electron microscopic study. Various
treatments were introduced to the patient without clinical improvement, including cholestyramine,
metronidazole, probiotics, and octreotide. He was dependent on total parenteral nutrition and sub-
sequently died from TPN-related complications. Even though it is a rare disease, it should be con-
sidered if an infant has chronic secretory diarrhea.
Key word : Microvillus Inclusion Disease, Chronic Secretory Diarrhea, Diagnosis, Ultrastructure
Pathology
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