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Original ArticleOpen Access
Serum Nitric Oxide Levels in Patients with Coronary Artery Diseases
Akarasereenont P 
,
Leowattana W ,
Nuamchit T ,
Chotewuttakorn S ,
Thaworn A ,
Khunawat P
,
Leowattana W ,
Nuamchit T ,
Chotewuttakorn S ,
Thaworn A ,
Khunawat P WATTANA LEOWATTANA, M.D.**,
SIRIKUL CHOTEWUTTAKORN, M.Sc. *,
PANYA KHUNAWAT,M.D.,Ph.D.*
Nitric oxide (NO) plays a pivotal role in the pathophysiology of coronary artery disease.
The roles of NO are not only physiological but also pathological in the cardiovascular system. An
inappropriate release of NO has been linked to the pathogenesis of CAD. The authors investi-
gated whether serum NOx (nitrate and nitrite), a stable end product of NO, level was related to
patients with coronary artery disease. The blood chemistry, such as cholesterol, triglyceride, LDL-C,
HDL-C and blood sugar, was also measured in comparison with serum NOx. Serum NOx was
measured in samples from 20 healthy controls, 20 angina patients without angiographic evidence
of coronary lesions (CAG) and 20 angina patients with angiographic evidence of coronary lesions
(CAD) by using modified Griess reaction. The mean serum NOx levels in the CAD groups was
higher than CAG and control groups (41.3
เธ‘
5.5, 32.7
เธ‘
3.9 and 25.7
เธ‘
3.5 Jlmol/L, respectively).
NOx levels in the CAD group was only significantly higher than the control groups (p
<
0.05) but
not the CAG groups. There were no significant differences of NOx levels in all age groups. In the
CAD group, women showed significantly higher NOx levels than men (64.0
เธ‘
7.5 and 29.0
เธ‘
4.7
Jlmol/L, respectively, p
<
0.05). Interestingly, the mean serum NOx levels in the CAD groups was
significantly higher in a group of abnormal lipid profiles (cholesterol, triglyceride, LDL-C) and
blood sugar than in a group of normal profiles. The results suggested that there was an increased
NOx levels in patients with coronary artery disease and much higher in patients with multiple
underlying conditions such as hyperlipidemia and hyperglycemia. Thus, the measurement of the
NOx levels at different times may help to monitor the state and severity of coronary artery disease.
Key word : Coronary Artery Diseases, Nitric Oxide, Serum, Concentration, Chest Pain
SIRIKUL CHOTEWUTTAKORN, M.Sc. *,
PANYA KHUNAWAT,M.D.,Ph.D.*
Nitric oxide (NO) plays a pivotal role in the pathophysiology of coronary artery disease.
The roles of NO are not only physiological but also pathological in the cardiovascular system. An
inappropriate release of NO has been linked to the pathogenesis of CAD. The authors investi-
gated whether serum NOx (nitrate and nitrite), a stable end product of NO, level was related to
patients with coronary artery disease. The blood chemistry, such as cholesterol, triglyceride, LDL-C,
HDL-C and blood sugar, was also measured in comparison with serum NOx. Serum NOx was
measured in samples from 20 healthy controls, 20 angina patients without angiographic evidence
of coronary lesions (CAG) and 20 angina patients with angiographic evidence of coronary lesions
(CAD) by using modified Griess reaction. The mean serum NOx levels in the CAD groups was
higher than CAG and control groups (41.3
เธ‘
5.5, 32.7
เธ‘
3.9 and 25.7
เธ‘
3.5 Jlmol/L, respectively).
NOx levels in the CAD group was only significantly higher than the control groups (p
<
0.05) but
not the CAG groups. There were no significant differences of NOx levels in all age groups. In the
CAD group, women showed significantly higher NOx levels than men (64.0
เธ‘
7.5 and 29.0
เธ‘
4.7
Jlmol/L, respectively, p
<
0.05). Interestingly, the mean serum NOx levels in the CAD groups was
significantly higher in a group of abnormal lipid profiles (cholesterol, triglyceride, LDL-C) and
blood sugar than in a group of normal profiles. The results suggested that there was an increased
NOx levels in patients with coronary artery disease and much higher in patients with multiple
underlying conditions such as hyperlipidemia and hyperglycemia. Thus, the measurement of the
NOx levels at different times may help to monitor the state and severity of coronary artery disease.
Key word : Coronary Artery Diseases, Nitric Oxide, Serum, Concentration, Chest Pain
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