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Original ArticleOpen Access
Infective Endocarditis : Prevalence, Characteristics and Mortality in Khon Kaen, 1990-1999 1990-1999
Pachirat O 
,
Chetchotisakd P ,
Klungboonkrong V ,
Taweesangsuksakul P ,
Tantisirin C ,
Loapiboon M
,
Chetchotisakd P ,
Klungboonkrong V ,
Taweesangsuksakul P ,
Tantisirin C ,
Loapiboon M Objective: To update the prevalence, characteristics and mortality of infective endocar-
ditis in a tertiary care hospital in Khon Kaen, Thailand.
Backgrpund: Numerous studies have shown that the prevalence and course of infective
endocarditis remain unchanged inspite of the advance in treatment, diagnosis and of prophylactic
recommendations.
Method: The authors identified 160 patients from 1990-1999 with 86 per cent definite and
14 per cent possible endocarditis based on the Duke criteria. Data were collected from two tertiary
care hospitals.
Results: The prevalence was 4 patients per 1,000 hospital admissions. The mean age of the
106 male and 54 female patients was 39เธ‘16 years. Twenty-four percent of the patients had no
previously known heart disease. Native valve endocarditis was present in 95 per cent and prosthetic
valve endocarditis was diagnosed -in
5
per cent. Infective endocarditis was located on the aortic
valve in 42 per cent, the mitral valve in 43 per cent, both mitral and aortic valves in 9 per cent and
the tricuspid valve in 8 per cent. The infective organism was identified in only 62 per cent of cases.
Streptococci
was the most common in 43 per cent, followed by
Staphylococci
.in 16 per cent. During
the first month after admission, 45 per cent of the patients underwent surgery. In-hospital mortality
was 25 per cent.
Conclusion: Despite improved diagnostic techniques and aggressive surgical therapy,
infective endocarditis remains a serious problem associated with a high mortality in Khon Kaen.
Key word : Infective Endocarditis, Epidemiology, Microbiology, Mortality
ditis in a tertiary care hospital in Khon Kaen, Thailand.
Backgrpund: Numerous studies have shown that the prevalence and course of infective
endocarditis remain unchanged inspite of the advance in treatment, diagnosis and of prophylactic
recommendations.
Method: The authors identified 160 patients from 1990-1999 with 86 per cent definite and
14 per cent possible endocarditis based on the Duke criteria. Data were collected from two tertiary
care hospitals.
Results: The prevalence was 4 patients per 1,000 hospital admissions. The mean age of the
106 male and 54 female patients was 39เธ‘16 years. Twenty-four percent of the patients had no
previously known heart disease. Native valve endocarditis was present in 95 per cent and prosthetic
valve endocarditis was diagnosed -in
5
per cent. Infective endocarditis was located on the aortic
valve in 42 per cent, the mitral valve in 43 per cent, both mitral and aortic valves in 9 per cent and
the tricuspid valve in 8 per cent. The infective organism was identified in only 62 per cent of cases.
Streptococci
was the most common in 43 per cent, followed by
Staphylococci
.in 16 per cent. During
the first month after admission, 45 per cent of the patients underwent surgery. In-hospital mortality
was 25 per cent.
Conclusion: Despite improved diagnostic techniques and aggressive surgical therapy,
infective endocarditis remains a serious problem associated with a high mortality in Khon Kaen.
Key word : Infective Endocarditis, Epidemiology, Microbiology, Mortality
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