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Original ArticleOpen Access
Serum Estradiol and Follicle-Stimulating Hormone Levels in Thai Women Post Total Abdominal Hysterectomy and Bilateral Oophorectomy Using Oral 17 6-Estradiol
Bunyavejchevin S 
,
Panthong C ,
Limpaphayom KK
,
Panthong C ,
Limpaphayom KK Objective
: To assess the difference of serum estradiol (E
2
)
and follicle stimulating hor-
mone (FSH) levels in Thai women post total abdominal hysterectomy and bilateral oophorectomy,
before and after using a daily dose of 2 mg oral 17 P-estradiol.
Study design
: Experimental study (before and after treatment).
Setting
: Menopause Clinic, Department of Obstetrics and Gynecology, Faculty of Medi-
cine, Chulalongkom University.
Subjects
: Thirty-five women who had undergone total abdominal hysterectomy and
bilateral oophorectomy at Chulalongkom Hospital 1 week previously due to benign gynecologic
conditions were recruited in the study. Body mass index was 20-25 kg/m2
*
These women had no
contraindication for using hormonal replacement therapy and no history of any hormonal intake in
the past.
Intervention
: All subjects were assigned to receive a daily dose of 2 mg oral 17 P-estra-
diol applied at bedtime (8.00 p.m.).
Main outcome measures
: Serum E
2
and FSH were measured before and after the study
at weeks 4, 8 and 12, 12-14 hours after oral application. The hormonal measurement was performed
using the time-resolved fluoroimmunoassay (FIA) method.
Results
: Five cases were excluded, three cases due to poor compliance which was less
than 85 per cent and two cases due to loss to follow-up. Of the remaining 30 cases, the mean age
and body mass index were 43.03
เธ‘
4.58 years and 22.72
เธ‘
1.86 kg/m2
,
respectively. Serum E
2
level significantly increased from baseline value at 4, 8 and 12 weeks (median of E
2
value at 0,
4, 8 and 12 weeks : 20.00, 22.50, 324.65 and 355.35 pmol/L, p
: To assess the difference of serum estradiol (E
2
)
and follicle stimulating hor-
mone (FSH) levels in Thai women post total abdominal hysterectomy and bilateral oophorectomy,
before and after using a daily dose of 2 mg oral 17 P-estradiol.
Study design
: Experimental study (before and after treatment).
Setting
: Menopause Clinic, Department of Obstetrics and Gynecology, Faculty of Medi-
cine, Chulalongkom University.
Subjects
: Thirty-five women who had undergone total abdominal hysterectomy and
bilateral oophorectomy at Chulalongkom Hospital 1 week previously due to benign gynecologic
conditions were recruited in the study. Body mass index was 20-25 kg/m2
*
These women had no
contraindication for using hormonal replacement therapy and no history of any hormonal intake in
the past.
Intervention
: All subjects were assigned to receive a daily dose of 2 mg oral 17 P-estra-
diol applied at bedtime (8.00 p.m.).
Main outcome measures
: Serum E
2
and FSH were measured before and after the study
at weeks 4, 8 and 12, 12-14 hours after oral application. The hormonal measurement was performed
using the time-resolved fluoroimmunoassay (FIA) method.
Results
: Five cases were excluded, three cases due to poor compliance which was less
than 85 per cent and two cases due to loss to follow-up. Of the remaining 30 cases, the mean age
and body mass index were 43.03
เธ‘
4.58 years and 22.72
เธ‘
1.86 kg/m2
,
respectively. Serum E
2
level significantly increased from baseline value at 4, 8 and 12 weeks (median of E
2
value at 0,
4, 8 and 12 weeks : 20.00, 22.50, 324.65 and 355.35 pmol/L, p
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