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Original ArticleOpen Access
The Duration Time of Urine Morphine Detection in Heroin Addicts by Radioimmunoassay
Narongchai P 
,
Sribanditmonkol P ,
Thampithug S ,
Narongchai S ,
Chitivuthikam C
,
Sribanditmonkol P ,
Thampithug S ,
Narongchai S ,
Chitivuthikam C Heroin is one of the most seriously abused drugs and its consumption is illegal. There-
fore, the detection of the drug in addicts has to be highly accurate and reliable. Morphine detec-
tion in urine is the most common method to confirm consumption. Several methods of morphine
detection in urine are described such as Latex Agglutination Inhibition (LAI), Thin 'Layer Chromato-
graphy (TLC), Radioimmunoassay (RIA), High Performance Liquid Chromatography (HPLC) and
Gas Chromatography and Mass Spectrophotometry (GC/MS). In this study, we performed Radio-
immunoassay (RIA) because it is rapid and cheap. Sixty-three male heroin addicts, average age 32
years, with an average time of heroin administration of about 3 years were studied. They used on
average 0.635 -grams of heroin per day. The time of detection in the urine after the last heroin
administration to the first urine testing was about 8.5 hours, over 3-4 days. The amount of morphine
in the urine was 17,897.9 ng/ml. Nevertheless, we found that morphine could be detected in the
urine every day for seven days. The decreasing rate of daily morphine detection in the urine was
88.4, 74.2, 64.2, 57.1, 63.3 and 44.8 per cent. But there was no significant difference in the route
of administration.
Key word : Heroin, Radioimmunoassay, Morphine
fore, the detection of the drug in addicts has to be highly accurate and reliable. Morphine detec-
tion in urine is the most common method to confirm consumption. Several methods of morphine
detection in urine are described such as Latex Agglutination Inhibition (LAI), Thin 'Layer Chromato-
graphy (TLC), Radioimmunoassay (RIA), High Performance Liquid Chromatography (HPLC) and
Gas Chromatography and Mass Spectrophotometry (GC/MS). In this study, we performed Radio-
immunoassay (RIA) because it is rapid and cheap. Sixty-three male heroin addicts, average age 32
years, with an average time of heroin administration of about 3 years were studied. They used on
average 0.635 -grams of heroin per day. The time of detection in the urine after the last heroin
administration to the first urine testing was about 8.5 hours, over 3-4 days. The amount of morphine
in the urine was 17,897.9 ng/ml. Nevertheless, we found that morphine could be detected in the
urine every day for seven days. The decreasing rate of daily morphine detection in the urine was
88.4, 74.2, 64.2, 57.1, 63.3 and 44.8 per cent. But there was no significant difference in the route
of administration.
Key word : Heroin, Radioimmunoassay, Morphine
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