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Original ArticleOpen Access
Effectiveness of Ranitidine Bismuth Citrate Based Triple Therapy for Treating Helicobacter pylori
ThongNgam D 
,
Tangkijvanich P ,
Treeprasertsuk S ,
Wisedopas N ,
Kullavanijaya P
,
Tangkijvanich P ,
Treeprasertsuk S ,
Wisedopas N ,
Kullavanijaya P PISIT TANGKUVANICH, M.D.**,
NARUEMON WISEDOPAS, M.D.****,
Objective
: To determine the efficacy, safety and tolerance of a one week regimen of RBC,
clarithromycin, and amoxicillin for
H. pylori
eradication in Thai patients.
Material and Method
: Patients who were undergoing endoscopy for dyspeptic symptoms.
On the day of endoscopy, three biopsies were taken for
H. pylori
diagnosis. The patients who had
the presence of
H. pylori
infection by positive from rapid urease test or histologic examination were
invited to take part in an open, prospective study. Patients received a combination of RBC 400 mg,
clarithromycin 500 mg, and amoxicillin 1 g twice daily for 7 days. Repeated endoscopy was per-
formed to evaluate
H. pylori
eradication at least 1 month after the end of treatment. Clinical symp-
toms, side effects and compliance were assessed by interview during the study and at follow-up.
Results
: Tmrty nine patients with
H. pylori
infection were induded. Male and female
rates was 27 : 12 with a mean age of 42.8
เธ‘
11.4 years (range 21-68). There was a 89.74 per cent
eradication rate by intent-to-treat and 94.59 per cent by per-protocol analysis. There were no serious
adverse events during the study. Two patients (5.13%) stopped the medication because of side effects.
Two patients had failure' to eradication after complete treatment. Subjective improvement of the cli-
nical symptoms was found in 92.3 per cent.
Conclusion
: One week's regimen of RBC, clarithromycin, and amoxicillin triple therapy
resulted in a relatively high efficacy, safety and tolerance for
H. pylori
eradication in Thai patients.
Key word
: Ranitidine Bismuth Citrate, Triple Therapy,
Helicobacter pylori
NARUEMON WISEDOPAS, M.D.****,
Objective
: To determine the efficacy, safety and tolerance of a one week regimen of RBC,
clarithromycin, and amoxicillin for
H. pylori
eradication in Thai patients.
Material and Method
: Patients who were undergoing endoscopy for dyspeptic symptoms.
On the day of endoscopy, three biopsies were taken for
H. pylori
diagnosis. The patients who had
the presence of
H. pylori
infection by positive from rapid urease test or histologic examination were
invited to take part in an open, prospective study. Patients received a combination of RBC 400 mg,
clarithromycin 500 mg, and amoxicillin 1 g twice daily for 7 days. Repeated endoscopy was per-
formed to evaluate
H. pylori
eradication at least 1 month after the end of treatment. Clinical symp-
toms, side effects and compliance were assessed by interview during the study and at follow-up.
Results
: Tmrty nine patients with
H. pylori
infection were induded. Male and female
rates was 27 : 12 with a mean age of 42.8
เธ‘
11.4 years (range 21-68). There was a 89.74 per cent
eradication rate by intent-to-treat and 94.59 per cent by per-protocol analysis. There were no serious
adverse events during the study. Two patients (5.13%) stopped the medication because of side effects.
Two patients had failure' to eradication after complete treatment. Subjective improvement of the cli-
nical symptoms was found in 92.3 per cent.
Conclusion
: One week's regimen of RBC, clarithromycin, and amoxicillin triple therapy
resulted in a relatively high efficacy, safety and tolerance for
H. pylori
eradication in Thai patients.
Key word
: Ranitidine Bismuth Citrate, Triple Therapy,
Helicobacter pylori
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