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Original ArticleOpen Access
Blood Pressure Response to Antihypertensive Agents Related to Baseline Blood Pressure
Sermswan A 
,
Uboldejpracharak Y ,
Suthichaiyakul T ,
Sukontasam A ,
Buranakitcharoen P
,
Uboldejpracharak Y ,
Suthichaiyakul T ,
Sukontasam A ,
Buranakitcharoen P Prevalence of white-coat hypertension varies approximately 20 per cent among mild hyper-
tensives. When white-coat hypertensives are prescribed antihypertensive medication, there is usually
a decrease in clinic blood pressure (BP), but little or no change in 24 hours blood pressure (ABPM).
The objective of the study was to test the hypothesis that efficacy of medication therapy for hyper-
tension is identical in any grading of severity of baseline blood pressure. The authors retrospectively
analysed ABPM data from mild to moderate hypertensive patients. Efficacy in decreasing blood pres-
sure by antihypertensives has linear relation to baseline blood pressure. Response to antihypertensive
agents in white-coat hypertension is minimal but a significant effect still persists and the possibility
of hypotensive adverse events from medication in the case cannot be overlooked.
Key word : Ambulatory Blood Pressure Monitoring, Hypertension, White-Coat Hypertension,
Amlodipine, Mibefradil
tensives. When white-coat hypertensives are prescribed antihypertensive medication, there is usually
a decrease in clinic blood pressure (BP), but little or no change in 24 hours blood pressure (ABPM).
The objective of the study was to test the hypothesis that efficacy of medication therapy for hyper-
tension is identical in any grading of severity of baseline blood pressure. The authors retrospectively
analysed ABPM data from mild to moderate hypertensive patients. Efficacy in decreasing blood pres-
sure by antihypertensives has linear relation to baseline blood pressure. Response to antihypertensive
agents in white-coat hypertension is minimal but a significant effect still persists and the possibility
of hypotensive adverse events from medication in the case cannot be overlooked.
Key word : Ambulatory Blood Pressure Monitoring, Hypertension, White-Coat Hypertension,
Amlodipine, Mibefradil
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