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Case ReportOpen Access
Detection of JC Virus Infection in Progressive Multifocal Leukoencephalopathy: The First Documented Case in Thailand
Dujneungkunakom T ,
Sungkanuparph S ,
Vibhagool A ,
Pairoj W ,
Chantratita W ,
Srichunrusami C ,
Laothamatas J ,
Pulkes T
Progressive Multifocal Leukoencephalopathy (PML) is a demyelinating brain disease caused
by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in
AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging
diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clini-
cal and neuroradiological findings. The authors report a 36-year-old woman who presented with
prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI
findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This
report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the
need for a brain biopsy in such cases.
Key word : Progressive Multifocal Leukoencephalopathy, JC Virus, PCR
by human polyoma JC virus (JCV). This disease is an important cause of morbidity and mortality in
AIDS patients. Definite diagnosis currently requires a brain biopsy. PCR for JCV of CSF, an emerging
diagnostic tool, has a high specificity for the diagnosis of PML in patients with characteristics on clini-
cal and neuroradiological findings. The authors report a 36-year-old woman who presented with
prolonged fever, progressive weakness, and slow speech for 2 months. Clinical features and MRI
findings were compatible with PML. Qualitative PCR for JCV of CSF showed a positive result. This
report emphasizes the yield of PCR, the CSF for JCV in a diagnosis of PML, which may reduce the
need for a brain biopsy in such cases.
Key word : Progressive Multifocal Leukoencephalopathy, JC Virus, PCR
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