J Med Assoc Thai 2002; 85 (11):1169

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Effectiveness of Intravenous Meperidine for Pain Relief in the First Stage of Labour
Soontrapa S Mail, Somboonporn W , Komwilaisak R , Sookpanya S

Objective : To determine the effectiveness and side effects of intravenous meperidine in
labour pain relief.
Material and Method : A double blind, randomized controlled trial was conducted in 84
parturients, using normal saline as control. Visual analogue scale, postpartum parturients' opinion
of effectiveness, sedative scores, nausea/vomiting, dizziness, delivery method, Apgar scores, and
naloxone prescription were assessed.
Result : There were no statistically significant differences between the mean and median
of visual analogue scale of meperidine and control group. In addition, the sedative scores, nausea/
vomiting and dizziness in the meperidine group occurred more than those in the control group
significantly. Even mean of the pain increment in the meperidine group was less than those in the
control group (p
0.05). The parturients' opinion on the effectiveness of pain relief during labor within
24 hours of the first postpartum day was only 23.80 per cent in the meperidine group, however, it
was statistically significantly different when compared to 7.10 per cent in the control group.
Conclusion : Intravenous meperidine exhibited the effectiveness of pain relief of only 23.80
per cent of the subjects, in addition, it may cause many side effects.
Key word : Meperidine, Pain Relief, Labour Pain

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