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Original ArticleOpen Access
Antiseptics for Preventing Omphalitis
Panyavudhikrai S 
,
Kolatat T ,
Danchaivijitr S ,
Dhiraputra C ,
Vantanasiri C ,
Poomsuwan V ,
Trakulsomboon S ,
Srihapol N
,
Kolatat T ,
Danchaivijitr S ,
Dhiraputra C ,
Vantanasiri C ,
Poomsuwan V ,
Trakulsomboon S ,
Srihapol N THRATHIP KOLA TAT, M.D.*,
CHERTSAK DHIRAPUTRA, M.D.***,
VARAPORN POOMSUWAN, R.N.**,
NITAYA SRIHAPOL, R.N.**
Background
: Omphalitis may cause serious complications and contribute to neonatal
morbidity and mortality. From January 1997 to August 1998, the incidence of omphalitis in the
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital had been increased
from 0.9 to 17.4 per 1000 live births. A prospective randomized trial using antiseptic applied directly
to the umbilical stump was conducted aiming to reduce an epidemic outbreak of omphalitis in the
newborn nursery.
Objective
: To determine which antiseptic is appropriate for preventing omphalitis in the
newborn infants.
Patients and Method
: Newborn infants delivered in the Department of Obstetrics and
Gynecology, Faculty of Medicine Siriraj Hospital were randomized into group A (Triple dye) or
group B (70% Alcohol). The infant with omphalitis was assessed by a pediatrician or a neonatology
fellow. At home, the same antiseptic will be continually applied to the umbilical stump daily until
a few days after cord detachment. Relative risk was calculated and statistical significance was tested
by Chi-square test.
Results
: Four hundred and twenty-seven infants were enrolled. Birth weight, gestational
age and gender of the infants in both groups were not different. There were no known maternal risk
factors for omphalitis. Omphalitis was observed in 9/213 (4.2%) infants in group A and 23/214
(10.7%) infants in group
B.
The relative incidence rate between each group was statistically signi-
ficant (p
CHERTSAK DHIRAPUTRA, M.D.***,
VARAPORN POOMSUWAN, R.N.**,
NITAYA SRIHAPOL, R.N.**
Background
: Omphalitis may cause serious complications and contribute to neonatal
morbidity and mortality. From January 1997 to August 1998, the incidence of omphalitis in the
Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital had been increased
from 0.9 to 17.4 per 1000 live births. A prospective randomized trial using antiseptic applied directly
to the umbilical stump was conducted aiming to reduce an epidemic outbreak of omphalitis in the
newborn nursery.
Objective
: To determine which antiseptic is appropriate for preventing omphalitis in the
newborn infants.
Patients and Method
: Newborn infants delivered in the Department of Obstetrics and
Gynecology, Faculty of Medicine Siriraj Hospital were randomized into group A (Triple dye) or
group B (70% Alcohol). The infant with omphalitis was assessed by a pediatrician or a neonatology
fellow. At home, the same antiseptic will be continually applied to the umbilical stump daily until
a few days after cord detachment. Relative risk was calculated and statistical significance was tested
by Chi-square test.
Results
: Four hundred and twenty-seven infants were enrolled. Birth weight, gestational
age and gender of the infants in both groups were not different. There were no known maternal risk
factors for omphalitis. Omphalitis was observed in 9/213 (4.2%) infants in group A and 23/214
(10.7%) infants in group
B.
The relative incidence rate between each group was statistically signi-
ficant (p
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