J Med Assoc Thai 2002; 85 (2):263

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Drug Eruptions : The Value of Oral Rechalleng Test and Patch Test
Puavilai S Mail, Kamtavee S , Chunharas A , Pongwiriyapanich S

All in-and out-patients, who came for drug eruption consultation at the Dermatology Clinic,
Ramathibodi Hospital from December 1997 to November 1998 were included in this study. Medical
histories and physical examinations were performed by one of the authors. In suspected cases, a
skin biopsy was performed to confirm the diagnosis. Patch test and oral challenge test were per-
formed in some patients who had maculopapular, fixed drug eruption and acute generalized exan-
thematous pustulosis, with informed consent.
Among 80 patients, the most common cutaneous reaction was maculopapular rash. Anti-
microbial drugs were the most common causative agents. The patch test was positive in only one
patient from
12
cases. The oral provocative test was positive in two patients from
4
cases.
It is concluded that oral provocative test is still necessary to get a definite diagnosis of
causative agent. The value of patch test needs further study.
Key word : Drug Eruption, Oral Challenge Test, Patch Test

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