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Original ArticleOpen Access
Misoprostal Use for Therapeutic Abortion in Siriraj Hospital : The Year 2000
Sirimai K 
,
Kiriwat O ,
Neungton S ,
Suvanichchati S
,
Kiriwat O ,
Neungton S ,
Suvanichchati S ORAWAN KIRIWAT,M.D.*,
SUKANDA SUVANICHCHATI,M.S.W.*
Objective
: To evaluate the efficacy and the adverse effects of misoprostal usage for thera-
peutic abortion in Siriraj Hospital.
Study design
: Cross-sectional, descriptive study.
Material and Method
: A consecutive series of 101 therapeutic abortions was performed
in the Department of Obstetrics & Gynecology, Siriraj Hospital in the year 2000. The patients were
interviewed for general information and registered, as well as in-patient data. Any adverse events
were recorded and collected from the inpatient record file. All data were analyzed statistically.
Results
: 42 therapeutic abortions were conducted in association with misoprostal usage.
Misoprostal was used for cervical ripening in 8 patients with a good outcome. 31 therapeutic abor-
tions were induced by misoprostal alone regimen. A higher success rate (74.1%) was correlated with
higher gestational age. 27 out of 31 cases were second trimester abortion. The induction to abortion
interval was 18.0เธ‘10.5 hours (range 5-48). No factor, including age, weight, total dose of miso-
prostal use, nulliparity and viability of the fetus, could be demonstrated to affect the misoprostal
activity defined by induction to abortion interval. There was no serious adverse event, except for
severe abdominal cramping (26.2%) and fever (14.3%).
Conclusion
: Misoprostal alone can be used with caution for abortion induction especially
in second trimester abortion.
Key word
: Misoprostal, Therapeutic Abortion, Second Trimester Abortion
SUKANDA SUVANICHCHATI,M.S.W.*
Objective
: To evaluate the efficacy and the adverse effects of misoprostal usage for thera-
peutic abortion in Siriraj Hospital.
Study design
: Cross-sectional, descriptive study.
Material and Method
: A consecutive series of 101 therapeutic abortions was performed
in the Department of Obstetrics & Gynecology, Siriraj Hospital in the year 2000. The patients were
interviewed for general information and registered, as well as in-patient data. Any adverse events
were recorded and collected from the inpatient record file. All data were analyzed statistically.
Results
: 42 therapeutic abortions were conducted in association with misoprostal usage.
Misoprostal was used for cervical ripening in 8 patients with a good outcome. 31 therapeutic abor-
tions were induced by misoprostal alone regimen. A higher success rate (74.1%) was correlated with
higher gestational age. 27 out of 31 cases were second trimester abortion. The induction to abortion
interval was 18.0เธ‘10.5 hours (range 5-48). No factor, including age, weight, total dose of miso-
prostal use, nulliparity and viability of the fetus, could be demonstrated to affect the misoprostal
activity defined by induction to abortion interval. There was no serious adverse event, except for
severe abdominal cramping (26.2%) and fever (14.3%).
Conclusion
: Misoprostal alone can be used with caution for abortion induction especially
in second trimester abortion.
Key word
: Misoprostal, Therapeutic Abortion, Second Trimester Abortion
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