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Original ArticleOpen Access
Dose-Expanded Study in the Reinforcement of Efficacy of Simvastatin
Two hundred and twenty two hyperlipidemic patients were recruited for a 12-week pro-
spective, multicenter, open-label, titrate-to-goal study to evaluate the efficacy and safety of 20 to
40 mg per day of simvastatin in a Thai population. The efficacy on lipid lowering was evaluated
at 4 weeks and 8 weeks after medication. Based on NCEP A TP II guideline and ADA position
statement, subjects were categorized into three groups according to LDL-C goals; group 1: patients
without CHD and with
spective, multicenter, open-label, titrate-to-goal study to evaluate the efficacy and safety of 20 to
40 mg per day of simvastatin in a Thai population. The efficacy on lipid lowering was evaluated
at 4 weeks and 8 weeks after medication. Based on NCEP A TP II guideline and ADA position
statement, subjects were categorized into three groups according to LDL-C goals; group 1: patients
without CHD and with
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