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Original ArticleOpen Access
Risk of Breast Cancer in Post-Menopausal Women Using Hormone Replacement Therapy
Objective : To study the relationship of hormone replacement therapy (HRT) in post-meno-
pausal women and risk of breast cancer.
Patients and Method : The authors conducted a case-control study comparing the propor-
tion of HRT used between breast cancer and non-breast-cancer women. Cases were breast cancer
patients who had natural menopause (excluded hysterectomy) and aged ;;::50-years-old from the Siriraj
Breast Cancer database (1983-1996). Controls were post-menopausal volunteers aged 50 year or
older who visited Siriraj Hospital for other purposes such as elderly clinics, health check, etc. After
informed consent, well-trained surgeons examined the women in the control group to exclude any
potential breast cancer. Patient characteristics and risk factors were collected.
Results : Of 1913 patients in the database, 623 were included as the cases. Data from 679
volunteers were collected for controls from May to December 1999. Among 1302 of the study popu-
lation 58 women had ever used HRT (4.5%), which distributed to 3.2 per cent (20/623) in cases and
5.6 per cent (38/679) in controls. From univariate analysis, age, age at menopause, number of children,
habitat, education, contraceptive pills, familial history of breast cancer and HRT usage were asso-
ciated with breast cancer (p-value
pausal women and risk of breast cancer.
Patients and Method : The authors conducted a case-control study comparing the propor-
tion of HRT used between breast cancer and non-breast-cancer women. Cases were breast cancer
patients who had natural menopause (excluded hysterectomy) and aged ;;::50-years-old from the Siriraj
Breast Cancer database (1983-1996). Controls were post-menopausal volunteers aged 50 year or
older who visited Siriraj Hospital for other purposes such as elderly clinics, health check, etc. After
informed consent, well-trained surgeons examined the women in the control group to exclude any
potential breast cancer. Patient characteristics and risk factors were collected.
Results : Of 1913 patients in the database, 623 were included as the cases. Data from 679
volunteers were collected for controls from May to December 1999. Among 1302 of the study popu-
lation 58 women had ever used HRT (4.5%), which distributed to 3.2 per cent (20/623) in cases and
5.6 per cent (38/679) in controls. From univariate analysis, age, age at menopause, number of children,
habitat, education, contraceptive pills, familial history of breast cancer and HRT usage were asso-
ciated with breast cancer (p-value
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