J Med Assoc Thai 2002; 85 (7):789

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Comparative Study of the Efficacy of Topical Corticosteroid Five Locally Made and One Brand Name Creams
Puavilai S Mail, Noppakun N , Krisadaphong P , Charuwichitratana S , Leenutaphong V , Kulthanan K , Asawanonda P , Huiprasert P , Tresukosol P , Ploysangham T , Ophaswongse S , Ruangkarnchanasetr S

NOPADON NOPPAKUN, M.D.**,
SOMYOT CHARUWICHITRATANA, M.D.*,
KANOKVALAI KULTHANAN, M.D.****,
PORNTIP HUIPRASERT, M.D.**,
POOHGLIN TRESUKOSOL, M.D.*****,
SUWIRAKORN OPHASWONGSE, M.D.*******,
The aim of this study was to evaluate the efficacy of 5 locally made clobetasol propionate
creams compared with a brand name product.
The study was divided into 3 parts
1)
pharmacological study, 2) vasoconstriction test, and
3) double blind clinical trial.
The results showed that the pharmacological properties of the locally made products were
not different from the brand name product. Product C and D could diffuse through cellulose acetate
membrane 3 fold more than the brand name product. Product D and E caused less vasoconstriction
than the brand name product. This double blind study showed that all locally made products could
improve psoriasis to the same extent as the brand name product, but there was more recurrence of
psoriasis while using all the locally made products.
790

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