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Original ArticleOpen Access
Correlation Between Susceptibility of Mycobacterium tuberculosis by Microliter Plate Alamar Blue Assay and Clinical Outcomes
Sungkanuparph S 
,
Buabut B ,
Pracharktam R ,
Kiatatchasai W
,
Buabut B ,
Pracharktam R ,
Kiatatchasai W BENJAMAS BUABUT, B.Sc.**,
WIPHA WEE KIATATCHASAI, M.Ed. *,
A rapid, inexpensive, and reliable antimycobacterial susceptibility assay is needed to effec-
tively deal with the increasing prevalence of resistant strains of
M. tuberculosis
in Thailand. The
microtiter plate Alamar blue assay (MABA) appears to be promising but requires additional data
regarding correlation with clinical outcome. The correlation between the susceptibility by MABA and
clinical outcomes was studied. There were 123 specimens obtained from extra-pulmonary sites of 108
patients at Ramathibodi Hospital in 1999. The authors found that susceptibility of
M. tuberculosis
isolates by the MABA correlated with the clinical outcome; patients with isolates sensitive to iso-
niazid, rifampicin, and ethambutol had a better clinical outcome than patients with isolates resistant
to at least one of these drugs (p=0.004). Studies to determine this correlation in pulmonary tuber-
culosis are still needed.
Key word :
Mycobacterium tuberculosis,
Tuberculosis, Susceptibility, Correlation, Clinical Outcome
WIPHA WEE KIATATCHASAI, M.Ed. *,
A rapid, inexpensive, and reliable antimycobacterial susceptibility assay is needed to effec-
tively deal with the increasing prevalence of resistant strains of
M. tuberculosis
in Thailand. The
microtiter plate Alamar blue assay (MABA) appears to be promising but requires additional data
regarding correlation with clinical outcome. The correlation between the susceptibility by MABA and
clinical outcomes was studied. There were 123 specimens obtained from extra-pulmonary sites of 108
patients at Ramathibodi Hospital in 1999. The authors found that susceptibility of
M. tuberculosis
isolates by the MABA correlated with the clinical outcome; patients with isolates sensitive to iso-
niazid, rifampicin, and ethambutol had a better clinical outcome than patients with isolates resistant
to at least one of these drugs (p=0.004). Studies to determine this correlation in pulmonary tuber-
culosis are still needed.
Key word :
Mycobacterium tuberculosis,
Tuberculosis, Susceptibility, Correlation, Clinical Outcome
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