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Case ReportOpen Access
Kikuchi-Fujimoto's Disease, Histiocytic Necrotizing Lymphadenitis, Mimicking Systemic Lupus Erythematosus
Mootsikapun P 
,
Nanagara R
,
Nanagara R Kikuchi-Fujimoto's disease (KFD) or histiocytic necrotizing lymphadenitis is a self-limit-
ing condition characterized by fever, neutropenia and lymphadenopathy. It is rarely associated with
systemic lupus erythematosus (SLE). The authors reported a case of Kikuchi's necrotizing lympha-
denitis who presented with fever, generalized lymphadenopathy, moderate leukopenia, polyarthritis,
vasculitis-like lesions and oral ulcers compatible with SLE but serologic tests for autoimmune disease
were all negative. The clinical symptoms resolved spontaneously within 3 months without any treat-
ment. Because there is an association between KFD and SLE, great care should be taken with a patient
who presents with either KFD or SLE.
Key word : Kikuchi-Fujimoto's Disease, Histiocytic Necrotizing Lymphadenitis, Systemic Lupus
Erythematosus
ing condition characterized by fever, neutropenia and lymphadenopathy. It is rarely associated with
systemic lupus erythematosus (SLE). The authors reported a case of Kikuchi's necrotizing lympha-
denitis who presented with fever, generalized lymphadenopathy, moderate leukopenia, polyarthritis,
vasculitis-like lesions and oral ulcers compatible with SLE but serologic tests for autoimmune disease
were all negative. The clinical symptoms resolved spontaneously within 3 months without any treat-
ment. Because there is an association between KFD and SLE, great care should be taken with a patient
who presents with either KFD or SLE.
Key word : Kikuchi-Fujimoto's Disease, Histiocytic Necrotizing Lymphadenitis, Systemic Lupus
Erythematosus
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