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Original ArticleOpen Access
Pulmonary Function in Infants Exposed to Pethidine
Kolatat T 
,
Jarungphan S ,
Charastong C ,
Jundeewong Y
,
Jarungphan S ,
Charastong C ,
Jundeewong Y SUPATTRA JARUNGPHAN, B.N.S.**,
YUPIN JUNDEEWONG, B.N.S. **
Objective : To investigate the effects of maternal pethidine administration on pulmonary
function tests in newborn infants.
Patients and Method : The study was carried out in the Department of Obstetrics and
Gynecology, Faculty of Medicine Siriraj Hospital. The study group consisted of 20 infants exposed
to pethidine within 4 hours prior to delivery. Twenty infants whose mothers received no analgesic
drug or regional anesthesia were randomly selected as the controls. Narcotic related respiratory
depression was determined by Apgar scores, the need for ventilatory support in the delivery room
and abnormal pulmonary function measurements.
Results : There was no difference in birth weight and gestational age between the two
groups of infants. Pethidine was given to mothers at a dose of 72.5
เธ‘
7.6 mglkg with a mean drug-
delivery interval of 152
เธ‘
61 minutes. One infant in each group had a !-minute Apgar score less than
7, but there was no statistical difference in the mean Apgar score between the two groups. None of
the infants whose mothers received pethidine required ventilatory support, but oxygen was provided
to eight infants who were apparently cyanosed at birth. Pulmonary function measurements were per-
formed at the age of 7.4
เธ‘
2.3 hours in the controls and 6.0
เธ‘
2.5 hours in the study group. There
was no significant difference in respiratory rate, tidal volume, inspiratory time, functional residual
capacity, compliance and resistance between the two groups of infants.
Conclusion : Severe narcotic related respiratory depression was uncommon in this study.
In the first 12 hours of life, there was no significant difference in pulmonary function of the infants
exposed to pethidine. It is quite safe to allow the baby to room-in with the mother if respiratory
depression is not presented at birth.
Key word : Pethidine, Meperidine, Pulmonary Function Testing, Neonate
YUPIN JUNDEEWONG, B.N.S. **
Objective : To investigate the effects of maternal pethidine administration on pulmonary
function tests in newborn infants.
Patients and Method : The study was carried out in the Department of Obstetrics and
Gynecology, Faculty of Medicine Siriraj Hospital. The study group consisted of 20 infants exposed
to pethidine within 4 hours prior to delivery. Twenty infants whose mothers received no analgesic
drug or regional anesthesia were randomly selected as the controls. Narcotic related respiratory
depression was determined by Apgar scores, the need for ventilatory support in the delivery room
and abnormal pulmonary function measurements.
Results : There was no difference in birth weight and gestational age between the two
groups of infants. Pethidine was given to mothers at a dose of 72.5
เธ‘
7.6 mglkg with a mean drug-
delivery interval of 152
เธ‘
61 minutes. One infant in each group had a !-minute Apgar score less than
7, but there was no statistical difference in the mean Apgar score between the two groups. None of
the infants whose mothers received pethidine required ventilatory support, but oxygen was provided
to eight infants who were apparently cyanosed at birth. Pulmonary function measurements were per-
formed at the age of 7.4
เธ‘
2.3 hours in the controls and 6.0
เธ‘
2.5 hours in the study group. There
was no significant difference in respiratory rate, tidal volume, inspiratory time, functional residual
capacity, compliance and resistance between the two groups of infants.
Conclusion : Severe narcotic related respiratory depression was uncommon in this study.
In the first 12 hours of life, there was no significant difference in pulmonary function of the infants
exposed to pethidine. It is quite safe to allow the baby to room-in with the mother if respiratory
depression is not presented at birth.
Key word : Pethidine, Meperidine, Pulmonary Function Testing, Neonate
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