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Original ArticleOpen Access
Effect of Red Blood CeU Glucose-6-Phosphate Dehydrogenase Deficiency on Patients with Dengue Hemorrhagic Fever
Tanphaichitr VS 
,
Suwantol L ,
PungAmritt P ,
Tachavanich K ,
Yogsan S ,
Viprakasit V
,
Suwantol L ,
PungAmritt P ,
Tachavanich K ,
Yogsan S ,
Viprakasit V RACHANEEKORN CHONLASIN, M.D.*,
PARICHAT PUNG-AMRITT, B.Sc.*,
SUTHEE YOGSAN, M.D.,
Ph.D.**,
Eighty nine males aged 1-13 years diagnosed with dengue haemorrhagic fever (DHF)
and admitted to the Department of Pediatrics Siriraj Hospital from March 1998 to April 2000 were
included in this study. 17 cases (19.1%) had red blood cell glucose-6-phosphate dehydrogenase (G-6-
PD) deficiency and 72 cases (80.9%) had normal G-6-PD enzyme activities. Most of the patients
were classified as DHF grade II in severity. 3 of 17 G-6-PD deficient cases had serious compli-
cations and all of them had acute intravascular hemolysis requiring blood transfusions. One of
these also had hematemesis, one had azothemia and the other one had renal failure and severe liver
failure with hepatic encephalopathy.
In the cases without obvious hemolytic or hepatic complications, G-6-PD deficient cases
had mildly but significantly higher total birirubin and indirect bilirubin, as well as a lower hema-
tocrit than those who had normal G-6-PD. Reticulocyte count was low during the acute phase,
however, during recovery, the levels were significantly increased in both groups. In the non G-6-PD
deficient group, G-6-PD enzyme levels were significantly decreased during the acute phase com-
pared to the normal controls but rose significantly to normal levels during the recovery phase. There
were no statistically significant differences in other laboratory data. All patients recovered fully from
DHF.
Vol. 85 Suppl 2
EFFECT OF G-6-PD DEFICIENCY ON PATIENTS WITH DHF
S523
The prevalence of G-6-PD deficiency in male patients who had DHF in this study was 19.1
per cent which was higher than the prevalence in a previous study of 12 per cent in Bangkok.
This may imply that G-6-PD deficient males suffer more from DHF compared to normal G-6-PD
subjects.
Key word : G-6-PD Deficiency, Dengue Hemorrhagic Fever, Liver Failure, Acute Hemolysis
PARICHAT PUNG-AMRITT, B.Sc.*,
SUTHEE YOGSAN, M.D.,
Ph.D.**,
Eighty nine males aged 1-13 years diagnosed with dengue haemorrhagic fever (DHF)
and admitted to the Department of Pediatrics Siriraj Hospital from March 1998 to April 2000 were
included in this study. 17 cases (19.1%) had red blood cell glucose-6-phosphate dehydrogenase (G-6-
PD) deficiency and 72 cases (80.9%) had normal G-6-PD enzyme activities. Most of the patients
were classified as DHF grade II in severity. 3 of 17 G-6-PD deficient cases had serious compli-
cations and all of them had acute intravascular hemolysis requiring blood transfusions. One of
these also had hematemesis, one had azothemia and the other one had renal failure and severe liver
failure with hepatic encephalopathy.
In the cases without obvious hemolytic or hepatic complications, G-6-PD deficient cases
had mildly but significantly higher total birirubin and indirect bilirubin, as well as a lower hema-
tocrit than those who had normal G-6-PD. Reticulocyte count was low during the acute phase,
however, during recovery, the levels were significantly increased in both groups. In the non G-6-PD
deficient group, G-6-PD enzyme levels were significantly decreased during the acute phase com-
pared to the normal controls but rose significantly to normal levels during the recovery phase. There
were no statistically significant differences in other laboratory data. All patients recovered fully from
DHF.
Vol. 85 Suppl 2
EFFECT OF G-6-PD DEFICIENCY ON PATIENTS WITH DHF
S523
The prevalence of G-6-PD deficiency in male patients who had DHF in this study was 19.1
per cent which was higher than the prevalence in a previous study of 12 per cent in Bangkok.
This may imply that G-6-PD deficient males suffer more from DHF compared to normal G-6-PD
subjects.
Key word : G-6-PD Deficiency, Dengue Hemorrhagic Fever, Liver Failure, Acute Hemolysis
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