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Original ArticleOpen Access
Thrombotic Complications During Induction Chemotherapy of Acute Childhood Lymphoblastic Leukemia
Kankirawatana S 
,
Veerakul G ,
Sanpakit K ,
Tanphaichitr VS ,
Akkabutr P ,
Suwantol L ,
Mahasandana C
,
Veerakul G ,
Sanpakit K ,
Tanphaichitr VS ,
Akkabutr P ,
Suwantol L ,
Mahasandana C The incidence of thrombosis during induction chemotherapy of acute childhood lympho-
blastic leukemia (ALL) patients was 6 found to be in 105 (5.7%). There were 4 cerebral infarctions,
1 superior vena cava (SVC) obstruction and 1 deep vein thrombosis. Among these, 2 of them
died. A prospective study was further conducted of the change in coagulation and anticoagulation
factors during 6 weeks of induction chemotherapy. It was found that the activated partial thrombo-
plastin time (aPTf) was within normal range in all cases throughout 6 weeks, while prothrombin
time (PT) and thrombin time (TI) were slightly prolonged, especially during the first 3 weeks of this
phase. The natural anticoagulant panels which included protein C (PC), protein S (PS) and anti-
thrombin III (AT III) and also fibrinogen level, were lower during the first 3 weeks and reached its
nadir during the second and third week. The lower level of natural anticoagulants might be an impor-
tant predisposing factor for the occurrence of thrombosis in these patients.
Key word : Thrombosis, Induction Chemotherapy, Acute Childhood Lymphoblastic Leukemia
blastic leukemia (ALL) patients was 6 found to be in 105 (5.7%). There were 4 cerebral infarctions,
1 superior vena cava (SVC) obstruction and 1 deep vein thrombosis. Among these, 2 of them
died. A prospective study was further conducted of the change in coagulation and anticoagulation
factors during 6 weeks of induction chemotherapy. It was found that the activated partial thrombo-
plastin time (aPTf) was within normal range in all cases throughout 6 weeks, while prothrombin
time (PT) and thrombin time (TI) were slightly prolonged, especially during the first 3 weeks of this
phase. The natural anticoagulant panels which included protein C (PC), protein S (PS) and anti-
thrombin III (AT III) and also fibrinogen level, were lower during the first 3 weeks and reached its
nadir during the second and third week. The lower level of natural anticoagulants might be an impor-
tant predisposing factor for the occurrence of thrombosis in these patients.
Key word : Thrombosis, Induction Chemotherapy, Acute Childhood Lymphoblastic Leukemia
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