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Original ArticleOpen Access
Combination Vaccines
Chokephaibulkit K 
Recently multiple individual vaccines were put together into one syringe. This is ideal to
simplify the administration of vaccines and reduce emotional distress from multiple injections.
However, combination of many vaccines may interfere with the properties of each individual antigen
and complicate the schedule. From earlier studies, most of the combinations of diphtheria-tetanus-
pertussis (whole-cell) vaccine (DTPw),
Haemophilus influenzae
type b vaccine (Hib), hepatitis B vaccine
(HBV), and inactivated polio vaccine (IPV) were safe and adequately immunogenic. On the other
hand, there was a notable reduction in anti-PRP when Hib was combined with acellular pertussis vac-
cine (DTPa). Combination of hepatitis A vaccine and HBV was safe and effective. Those coming soon
in the pipeline are DTPa-Hib-HBV, MMR-varicella, pneumococcal-meningococcal. With the increase
in demand, health-care providers need to be acquainted to these combination vaccines. The bottom line
is to make sure that the children get vaccination appropriately.
Key word: Combine Vaccines, Vaccines, Immunization, Children
simplify the administration of vaccines and reduce emotional distress from multiple injections.
However, combination of many vaccines may interfere with the properties of each individual antigen
and complicate the schedule. From earlier studies, most of the combinations of diphtheria-tetanus-
pertussis (whole-cell) vaccine (DTPw),
Haemophilus influenzae
type b vaccine (Hib), hepatitis B vaccine
(HBV), and inactivated polio vaccine (IPV) were safe and adequately immunogenic. On the other
hand, there was a notable reduction in anti-PRP when Hib was combined with acellular pertussis vac-
cine (DTPa). Combination of hepatitis A vaccine and HBV was safe and effective. Those coming soon
in the pipeline are DTPa-Hib-HBV, MMR-varicella, pneumococcal-meningococcal. With the increase
in demand, health-care providers need to be acquainted to these combination vaccines. The bottom line
is to make sure that the children get vaccination appropriately.
Key word: Combine Vaccines, Vaccines, Immunization, Children
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