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Original ArticleOpen Access
Management of Severe Atopic Dermatitis with Thymostimulin
Wisuthsarewong W 
,
Viravan S
,
Viravan S Two patients with severe atopic dermatitis unresponsive to conventional therapy were
enrolled in a clinical trial on thymostimulin (TP-1). TP-1 was administered by subcutaneous
injection 1 mglkg/day for 14 days and then 1 mglk.g/day on alternate days for 2 months. Clinical
and immunological status were evaluated at baseline and at regular intervals during the treatment.
Clinical severity scores included eight skin conditions (erythema, edema, vesicle, crust, excoria-
tion, scaling, lichenification, pigmentation), two subjective components (itchiness and loss of sleep),
and extent of area affected. There was a statistically significant improvement in the overall assess-
ment of the severity scores. There were no definite changes in immunological parameters including
CD
4
,
CD
8
T-cell subpopulations and serum lgE, but eosinophil count showed a mark decrease in
one case. No serious side effects were observed.
Key
word
: Atopic Dermatitis, Thymostimulin
enrolled in a clinical trial on thymostimulin (TP-1). TP-1 was administered by subcutaneous
injection 1 mglkg/day for 14 days and then 1 mglk.g/day on alternate days for 2 months. Clinical
and immunological status were evaluated at baseline and at regular intervals during the treatment.
Clinical severity scores included eight skin conditions (erythema, edema, vesicle, crust, excoria-
tion, scaling, lichenification, pigmentation), two subjective components (itchiness and loss of sleep),
and extent of area affected. There was a statistically significant improvement in the overall assess-
ment of the severity scores. There were no definite changes in immunological parameters including
CD
4
,
CD
8
T-cell subpopulations and serum lgE, but eosinophil count showed a mark decrease in
one case. No serious side effects were observed.
Key
word
: Atopic Dermatitis, Thymostimulin
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