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Original ArticleOpen Access
Risperidone in the Treatment of Autistic Thai Children Under 4 Years of Age
BoonYasidhi V 
,
Tarugsa J ,
Suwanwattana C ,
Soising L
,
Tarugsa J ,
Suwanwattana C ,
Soising L The authors report five cases of very young children with autistic disorder, aged 2.1-3.7
years, treated with risperidone, as part of the comprehensive intervention. Treatment with risperi-
done 0.25-0.5 mg per day was associated with clinically meaningful decreases in problem behaviors
including hyperactivity, irritability, and aggressiveness. There were also improvements in social
relatedness and cooperation with developmental treatment. All of the children tolerated the medica-
tion well and experienced no untoward effects. The efficacy of risperidone in the treatment of very
young children with autistic disorder reported here is consistent with findings in the limited number
of cases previously reported in the literature. Controlled studies are needed to confirm the efficacy
and safety of risperidone in the treatment of these children.
Key word : Risperidone, Autistic, Pervasive Developmental Disorders
years, treated with risperidone, as part of the comprehensive intervention. Treatment with risperi-
done 0.25-0.5 mg per day was associated with clinically meaningful decreases in problem behaviors
including hyperactivity, irritability, and aggressiveness. There were also improvements in social
relatedness and cooperation with developmental treatment. All of the children tolerated the medica-
tion well and experienced no untoward effects. The efficacy of risperidone in the treatment of very
young children with autistic disorder reported here is consistent with findings in the limited number
of cases previously reported in the literature. Controlled studies are needed to confirm the efficacy
and safety of risperidone in the treatment of these children.
Key word : Risperidone, Autistic, Pervasive Developmental Disorders
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