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Original ArticleOpen Access
Analgesic Effect of Intraperitoneal Instillation ofBupivacaine for Postoperative Laparoscopic Cholecystectomy
Jiranantarat V 
,
Rushatamukayanunt W ,
-Akyamanee NL ,
Siruearanai R ,
Piromrat I ,
Suwannanonda P ,
Muangkasem J
,
Rushatamukayanunt W ,
-Akyamanee NL ,
Siruearanai R ,
Piromrat I ,
Suwannanonda P ,
Muangkasem J Objective : To study the effectiveness of intraperitoneal instillation of bupivacaine for
postoperative laparoscopic cholecystectomy pain relief, especially specific pain (visceral pain, shoulder
pain and epigastric pain).
Patients and Method :Eighty ASA (American Society of Anesthesiologists) I and 2 patients
were randomly assigned to receive either 20 ml of 0.5 per cent bupivacaine (n=39) or the same
volume of saline (n=4I) instilled under direct vision into the hepatodiaphragmatic space, near and
above the hepatoduodenalligament and above the gall bladder bed at the end of surgery. The intensity
of visceral pain, shoulder pain and epigastric pain was assessed at I, 6, 24 and 48 h after surgery
using a visual analogue scale (IOO mm VAS) and verbal rating "Prince Henry" pain scale (VRS). The
time when analgesia was first required and total analgesic consumption were also recorded.
t-test,
Chi-square, Mann-Whitney U test and Kaplan-Meier survival analysis were used for statistical analy-
sis.
Results : Patient data were similar in the two groups except for body weight. There were
no statistical differences between the two groups for the time when analgesia was first required, VAS,
VRS and total analgesic consumption.
Conclusion : In this study, intraperitoneal instillation of bupivacaine does not show any
advantage for postoperative analgesia after laparoscopic cholecystectomy.
Key word : Pain, Laparoscopic Cholecystectomy, Bupivacaine
postoperative laparoscopic cholecystectomy pain relief, especially specific pain (visceral pain, shoulder
pain and epigastric pain).
Patients and Method :Eighty ASA (American Society of Anesthesiologists) I and 2 patients
were randomly assigned to receive either 20 ml of 0.5 per cent bupivacaine (n=39) or the same
volume of saline (n=4I) instilled under direct vision into the hepatodiaphragmatic space, near and
above the hepatoduodenalligament and above the gall bladder bed at the end of surgery. The intensity
of visceral pain, shoulder pain and epigastric pain was assessed at I, 6, 24 and 48 h after surgery
using a visual analogue scale (IOO mm VAS) and verbal rating "Prince Henry" pain scale (VRS). The
time when analgesia was first required and total analgesic consumption were also recorded.
t-test,
Chi-square, Mann-Whitney U test and Kaplan-Meier survival analysis were used for statistical analy-
sis.
Results : Patient data were similar in the two groups except for body weight. There were
no statistical differences between the two groups for the time when analgesia was first required, VAS,
VRS and total analgesic consumption.
Conclusion : In this study, intraperitoneal instillation of bupivacaine does not show any
advantage for postoperative analgesia after laparoscopic cholecystectomy.
Key word : Pain, Laparoscopic Cholecystectomy, Bupivacaine
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