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Original ArticleOpen Access
Can Lidocaine Reduce Succinylcholine Induced Postoperative Myalgia?
Amomyotin S 
,
Santawat U ,
Rachatamukayanant P ,
Nilsuwankosit P ,
Pipatnaraphong H
,
Santawat U ,
Rachatamukayanant P ,
Nilsuwankosit P ,
Pipatnaraphong H UBOLRAT SANTAWAT,M.D.*,
PASSAPORN NILSUWANKOSIT, M.D.*,
This study was undertaken to determine the effect of lidocaine pretreatment on reduction
of succinylcholine-induced myalgia in patients undergoing general anesthesia for gynecological
surgery. One hundred and thirty-five patients were assigned to one of three groups in a prospective,
double blind, randomized manner. Group PS, the control group, received normal saline and succinyl-
choline 1.5 mg.kg-
1
;
Group LS, lidocaine 1.5 mg.kg-
1
and succinylcholine 1.5 mg.kg-
1
;
Group PR,
normal saline and rocuronium 0.6 mg.kg-1
*
Morphine 0.1 mg.kg-1 iv was given for premedication and
all patients were monitored with a noninvasive blood pressure monitor, ECG and pulse oximetry.
Anesthesia was induced with 5 mg.kg-
1
thiopental iv. followed by succinylcholine (Group PS, LS)
or rocuronium (Group PR) for tracheal intubation. Following administration of these agents, the
presence, and degree of fasciculation were assessed visually on a four point scale by one investigator
who was blinded to the drug administered. The blood pressure and heart rate of each patient were
monitored on nine occasions. Twenty-four hours later, any myalgia experienced was assessed accord-
ing to a structured questionaire and graded by a four point scale by one investigator blinded to the
intraoperative management. The results indicate that muscle fasciculation was not found in Group
PR while the patients in Group LS had a lower incidence of muscle fasciculation than those in Group
PS (p
PASSAPORN NILSUWANKOSIT, M.D.*,
This study was undertaken to determine the effect of lidocaine pretreatment on reduction
of succinylcholine-induced myalgia in patients undergoing general anesthesia for gynecological
surgery. One hundred and thirty-five patients were assigned to one of three groups in a prospective,
double blind, randomized manner. Group PS, the control group, received normal saline and succinyl-
choline 1.5 mg.kg-
1
;
Group LS, lidocaine 1.5 mg.kg-
1
and succinylcholine 1.5 mg.kg-
1
;
Group PR,
normal saline and rocuronium 0.6 mg.kg-1
*
Morphine 0.1 mg.kg-1 iv was given for premedication and
all patients were monitored with a noninvasive blood pressure monitor, ECG and pulse oximetry.
Anesthesia was induced with 5 mg.kg-
1
thiopental iv. followed by succinylcholine (Group PS, LS)
or rocuronium (Group PR) for tracheal intubation. Following administration of these agents, the
presence, and degree of fasciculation were assessed visually on a four point scale by one investigator
who was blinded to the drug administered. The blood pressure and heart rate of each patient were
monitored on nine occasions. Twenty-four hours later, any myalgia experienced was assessed accord-
ing to a structured questionaire and graded by a four point scale by one investigator blinded to the
intraoperative management. The results indicate that muscle fasciculation was not found in Group
PR while the patients in Group LS had a lower incidence of muscle fasciculation than those in Group
PS (p
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