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Original ArticleOpen Access
Neurobiologic Risk Score and Long-term Developmental Outcomes of Premature Infants, Birth Weight Less Than 1,250 Grams
Objective : To determine whether neurobiologic risk score (NBRS) would continue to
correlate with developmental outcomes.
Method : An observational cohort consisting of 258 surviving infants who returned to the
follow-up clinic with a mean age 22 months' corrected age. Both univariate and multivariate analysis
were performed to identify risk factors and to assess the predictive value of NBRS.
Results : Forty-eight to 53 per cent of these infants had growth parameters < 25th percentile
for age. Seventeen and 18 per cent respectively had mental developmental index (MDI) and psychomotor
developmental index (PDI) on the Bayley Scales less than 70 and 14 per cent developed cerebral
palsy (CP). NBRS demonstrated a significant correlation with the outcome (p
correlate with developmental outcomes.
Method : An observational cohort consisting of 258 surviving infants who returned to the
follow-up clinic with a mean age 22 months' corrected age. Both univariate and multivariate analysis
were performed to identify risk factors and to assess the predictive value of NBRS.
Results : Forty-eight to 53 per cent of these infants had growth parameters < 25th percentile
for age. Seventeen and 18 per cent respectively had mental developmental index (MDI) and psychomotor
developmental index (PDI) on the Bayley Scales less than 70 and 14 per cent developed cerebral
palsy (CP). NBRS demonstrated a significant correlation with the outcome (p
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