J Med Assoc Thai 2003; 86 (10):897

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Relationship between Human Papilloma Virus Infection and Abnormal Pap Smear in HIV-Seropositive Women at Siriraj Hospital
Sirimai K Mail, Sutchritpongsa P , Chaisilwattana P , Laothong MK

PAVIT SUTCHRITPONGSA, MD*,
KW ANJIT LAOTHONG, BSc*
The purpose of this prospective study was to determine the prevalence of human papilloma-
virus and abnormal Pap smear in HIV -seropositive women, particularly in HIV -seropositive women
who undertook antiretroviral drug. The consecutive series of 178 HIV -seropositive women was enrolled
in the Department of Obstetrics and Gynecology, Siriraj Hospital. All general information and labora-
tory results of the patients were recorded. Pap smears are obtained from the endocervix, cervical trans-
formation zone and vagina by using a cotton tip stick and Ayre spatula, as described in the VCE tech-
nique. The patients were assigned into two groups, the AZT and non-AZT group. The comparison
between the groups was calculated statistically.
It
was found that 88 of 178 HIV-seropositive women (49.4%) undertook Zidovudine. The
prevalence of abnormal Pap smear in HIV -seropositive women, who had an abnormal Pap smear, was
59.6 per cent. However, the prevalence of human papilloma virus infection detected by Pap smear was
reported in 17 patients (9.6% ). There was no difference between the AZT and non-AZT group statis-
tically. There was a significantly higher probability of finding an abnormal Pap smear for cervical
dysplasia in HIV -seropositive women who were infected with human papilloma virus compared to.
It is concluded that there is a higher risk of developing cervical dysplasia in HIV -seroposi-
tive women who carry the human papillomavirus.
Key word : Human Papillomavirus, Abnormal Pap Smear, Human Immunodeficiency Virus

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