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Original ArticleOpen Access
Newborn Screening for Congenital Hypothyroidism in Khon Kaen University Hospital, the First Three Years, A Preliminary Report
Panamonta O 
,
Tuksapun MS ,
Kiatchoosakun P ,
Jirapradittha J ,
Kirdpon W ,
Loapaiboon PM
,
Tuksapun MS ,
Kiatchoosakun P ,
Jirapradittha J ,
Kirdpon W ,
Loapaiboon PM SUKANYA TUKSAPUN, MD*,
JUNY A JIRAPRADITTHA, MD*,
MALINEE LOAPAIBOON, PhD***
Between January 2000 and December 2002, 9,558 of 10,868 live births at Srinagarind Hospi-
tal, Khon Kaen University, Khon Kaen, Thailand, were screened for congenital hypothyroidism (CH).
Dried blood spot thyroid stimulating hormone (TSH) was collected at age 48 hours or older. The cut-off
TSH level for recall test was> 25 mulL. Serum thyroxine (T4), Free T4 and TSH were performed during
the confirmatory test. Six of 24 infants recalled for confirmatory thyroid function tests had abnormal
tests. Primary CH was confirmed in 3 infants and thyroxine treatment was given. Two of the three infants
had thyroid dysgenesis, one had normal thyroid gland. Three infants showed borderline CH from the
confirmatory test, only one had borderline CH from the second confirmatory test and also received
thyroxine treatment. Twenty infants with false positives during the screening and confirmatory tests were
regularly followed-up for growth, development and thyroid function tests. The incidence of primary CH
in this sole tertiary care government hospital in Northeast Thailand was 1 : 3,186. Routine newborn CH
screening would ensure early detection and treatment.
Key word : Congenital Hypothyroidism, Newborn Screening, Borderline Hypothyroidism, Thailand
JUNY A JIRAPRADITTHA, MD*,
MALINEE LOAPAIBOON, PhD***
Between January 2000 and December 2002, 9,558 of 10,868 live births at Srinagarind Hospi-
tal, Khon Kaen University, Khon Kaen, Thailand, were screened for congenital hypothyroidism (CH).
Dried blood spot thyroid stimulating hormone (TSH) was collected at age 48 hours or older. The cut-off
TSH level for recall test was> 25 mulL. Serum thyroxine (T4), Free T4 and TSH were performed during
the confirmatory test. Six of 24 infants recalled for confirmatory thyroid function tests had abnormal
tests. Primary CH was confirmed in 3 infants and thyroxine treatment was given. Two of the three infants
had thyroid dysgenesis, one had normal thyroid gland. Three infants showed borderline CH from the
confirmatory test, only one had borderline CH from the second confirmatory test and also received
thyroxine treatment. Twenty infants with false positives during the screening and confirmatory tests were
regularly followed-up for growth, development and thyroid function tests. The incidence of primary CH
in this sole tertiary care government hospital in Northeast Thailand was 1 : 3,186. Routine newborn CH
screening would ensure early detection and treatment.
Key word : Congenital Hypothyroidism, Newborn Screening, Borderline Hypothyroidism, Thailand
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