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Original ArticleOpen Access
Comparison of Topical Prednisolone Acetate, Ketorolac Tromethamine and Fluorometholone Acetate in Reducing Inflammation after Phacoemulsification
Trinavarat A 
,
Atchaneeyasakul L ,
Surachatkumtonekul T ,
Kosrirukvongs P
,
Atchaneeyasakul L ,
Surachatkumtonekul T ,
Kosrirukvongs P LA-ONGSRI ATCHANEEYASAKUL, MD*,
PANIDA KOSRIRUKVONGS, MD*
Aims : To compare the efficacy and ocular adverse effects of topical prednisolone acetate,
ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsifi-
cation.
Method : One hundred and twenty eyes were enrolled in a prospective, investigator-masked,
randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data
were recorded weekly: visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells
and flare in the anterior chamber, and ocular symptoms.
Results : The number of eyes with a minimal amount of cells in the anterior chamber in the
ketorolac group was less than the prednisolone group on day 7 (11:20, p
=
0.008) and day 14 (23:31,
p
=
0.015), and than fluorometholone group on day 7 (11:21, p
=
0.011). Intraocular pressure in the
prednisolone group was higher than the ketorolac group on day 21 (14.6: 12.2 mmHg, p
=
0.016). One
eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported
frequently in the ketorolac group.
Conclusion : All 3 drugs were effective in reducing post-operative inflammation. The effi-
cacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine
showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Key word : Prednisolone Acetate, Ketorolac Tromethamine, Fluorometholone Acetate, Phaco-
emulsification
PANIDA KOSRIRUKVONGS, MD*
Aims : To compare the efficacy and ocular adverse effects of topical prednisolone acetate,
ketorolac tromethamine, and fluorometholone acetate in reducing inflammation after phacoemulsifi-
cation.
Method : One hundred and twenty eyes were enrolled in a prospective, investigator-masked,
randomized controlled trial. Each drug was prescribed 4 times a day for 28 days. The following data
were recorded weekly: visual acuity, intraocular pressure, slit lamp biomicroscopy, grading of cells
and flare in the anterior chamber, and ocular symptoms.
Results : The number of eyes with a minimal amount of cells in the anterior chamber in the
ketorolac group was less than the prednisolone group on day 7 (11:20, p
=
0.008) and day 14 (23:31,
p
=
0.015), and than fluorometholone group on day 7 (11:21, p
=
0.011). Intraocular pressure in the
prednisolone group was higher than the ketorolac group on day 21 (14.6: 12.2 mmHg, p
=
0.016). One
eye in the prednisolone group had intraocular pressure of 32 mmHg. Burning sensation was reported
frequently in the ketorolac group.
Conclusion : All 3 drugs were effective in reducing post-operative inflammation. The effi-
cacy of prednisolone acetate and fluorometholone acetate was comparable. Ketorolac tromethamine
showed less efficacy than corticosteroids, however, it did not induce ocular hypertension.
Key word : Prednisolone Acetate, Ketorolac Tromethamine, Fluorometholone Acetate, Phaco-
emulsification
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