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Original ArticleOpen Access
Optic Neuritis : Characteristics and Visual Outcome
Chuenkongkaew W 
WANICHA CHUENKONGKAEW, MD*,
NIPHON CHIRAPAPAISAN, MD*
Objective : To determine clinical characteristics of patients with optic neuritis and visual
outcome after intravenous methylprednisolone treatment.
Method : A total of 81 patients with optic neuritis were reviewed retrospectively with regard
to their clinical characteristics by dividing into two groups as follows :-group I had isolated optic
neuritis and group II had optic neuritis with demyelinative disease. The visual outcome in these patients
before and after intravenous methylprednisolone treatment was analyzed.
Results : Of 81 patients with optic neuritis, 63 patients (77.8%) had isolated optic neuritis
and 18 (22.2%) patients were optic neuritis with demyelinative disease. The ages of the patients ranged
from 16 to 59 years (mean= 35.3 years) in patients with isolated optic neuritis and from 16 to 73 years
of age (mean = 35.8 years) in patients with optic neuritis with demyelinative disease. After treatment,
45 patients (52 eyes) with isolated optic neuritis and 14 patients (25 eyes) with optic neuritis with
demyelinative disease who were followed-up for more than 10 days were studied. After treatment,
60 per cent of the isolated optic neuritis patients and 24 per cent of the optic neuritis patients with
demyelinative disease had a visual acuity of 6112 or better respectively. The isolated optic neuritis
who had an onset interval to treatment of less than 8 days had a visual acuity better than 6/9 in 75 per
cent.
Conclusion : The final visual outcome in patients with isolated optic neuritis who received
earlier treatment was better than those who received treatment later.
Key word : Isolated Optic Neuritis, Optic Neuritis With Demyelinative Disease, Methylprednisolone,
Visual Outcome
NIPHON CHIRAPAPAISAN, MD*
Objective : To determine clinical characteristics of patients with optic neuritis and visual
outcome after intravenous methylprednisolone treatment.
Method : A total of 81 patients with optic neuritis were reviewed retrospectively with regard
to their clinical characteristics by dividing into two groups as follows :-group I had isolated optic
neuritis and group II had optic neuritis with demyelinative disease. The visual outcome in these patients
before and after intravenous methylprednisolone treatment was analyzed.
Results : Of 81 patients with optic neuritis, 63 patients (77.8%) had isolated optic neuritis
and 18 (22.2%) patients were optic neuritis with demyelinative disease. The ages of the patients ranged
from 16 to 59 years (mean= 35.3 years) in patients with isolated optic neuritis and from 16 to 73 years
of age (mean = 35.8 years) in patients with optic neuritis with demyelinative disease. After treatment,
45 patients (52 eyes) with isolated optic neuritis and 14 patients (25 eyes) with optic neuritis with
demyelinative disease who were followed-up for more than 10 days were studied. After treatment,
60 per cent of the isolated optic neuritis patients and 24 per cent of the optic neuritis patients with
demyelinative disease had a visual acuity of 6112 or better respectively. The isolated optic neuritis
who had an onset interval to treatment of less than 8 days had a visual acuity better than 6/9 in 75 per
cent.
Conclusion : The final visual outcome in patients with isolated optic neuritis who received
earlier treatment was better than those who received treatment later.
Key word : Isolated Optic Neuritis, Optic Neuritis With Demyelinative Disease, Methylprednisolone,
Visual Outcome
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