J Med Assoc Thai 2003; 86 (6):529

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Correlation of 4-and 24-hour Urine Protein in Women with Initially Diagnosed Hypertensive Disorders in Pregnancy
Wongkitisophon K Mail, Phupong V , Yamasmit W , Pansin P , Tannirandorn Y , Charoenvidhya D

VORAPONG PHUPONG, MD*,
PONGSAK PANSIN, BSc**,
DHIRAPHONGS CHAROENVIDHY A, MD*
Objective
: To determine whether 4-hour urine protein value correlates with 24-hour urine
protein value in women with hypertensive disorders in pregnancy.
Study design:
Cross-sectional study was performed in 38 in-patient pregnant women who
were initially diagnosed as having hypertensive disorders in pregnancy. Urine samples were collected
within 24 hours in 2 successive periods: the first 4-hour and the next 20-hour urine, in separate con-
tainers. The urine volume, urine protein and creatinine concentrations were thus separately measured.
The 4-and 24-hour urine proteins were calculated and the correlation between both groups was
determined by simple linear regression analysis.
Results
: A total of 38 patients were recruited into the study, 26 had mild preeclampsia, 5
had severe preeclampsia, and 7 had superimposed preeclampsia. The result of the 4-hour urine protein
was found to correlate with those of the 24-hour urine protein for patients with hypertensive disorders
in pregnancy (p
<
0.001).
Conclusion
: Total protein values of 4-hour samples positively correlated with values of
24-hour samples of patients with hypertensive disorders in pregnancy. This might be modified and
used for urine protein collection in outpatients to improve the compliance.
Key word
: Preeclampsia, Superimposed Preeclampsia, Proteinuria, 4-hour Urine, 24-hour Urine

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