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Original ArticleOpen Access
Hormonal Replacement Therapy in Surgical Menopause with Underlying Endometriosis
Rattanachaiyanont M 
,
Tanmahasamut P ,
Angsuwatthana S ,
Techatraisak K ,
lnthawiwat S ,
Leerasiri P
,
Tanmahasamut P ,
Angsuwatthana S ,
Techatraisak K ,
lnthawiwat S ,
Leerasiri P PRASONG TANMAHASAMUT, MD*,
KIT IRA T TECHA TRAISAK, MD*,
PICHAI LEERASIRI, MD*
Objective : To evaluate the effect of hormonal replacement therapy (HRT) regimens in surgi-
cal menopause patients with underlying endometriosis.
Design : Observational retrospective study.
Material and Method : 123 women with endometriosis after definite surgery (total abdo-
minal hysterectomy with bilateral salpingo-oophorectomy) were followed in the Gynecologic Endocrino-
logy and Menopause clinics. Patients were classified into 4 groups according to HRT regimens, i.e. control
(no HRT, n = 17), estrogen only (ERT, n =50), cyclic estrogen/progestin regimen (cyclic E/P, n =
16), and continuous combined estrogen/progestin (ccE/P, n
=
24). 12 patients who received more than
one regimen and 4 patients who received less than 6 months of HRT were excluded from the study.
The information was obtained from the medical records.
Results : Mean age at surgery of all patients was 38.9 years old. Mean duration of HRT was
41.2 months. There was no difference in age at surgery or duration of follow-up in each group. There
was 1 (2%) case of recurrent endometriosis and 3 (6%) cases of recurrent symptoms in the estrogen
only group; none of them required additional surgical treatment. Malignant transformation was not
found.
Conclusions : Although the present series is small, it seems that HRT is safe for postmeno-
pausal women with underlying endometriosis. Recurrence of endometriosis has rarely been a problem
with HRT, especially in those who received the combination of estrogen and progestin regimens.
Key word : Surgical Menopause, Endometriosis, HRT
KIT IRA T TECHA TRAISAK, MD*,
PICHAI LEERASIRI, MD*
Objective : To evaluate the effect of hormonal replacement therapy (HRT) regimens in surgi-
cal menopause patients with underlying endometriosis.
Design : Observational retrospective study.
Material and Method : 123 women with endometriosis after definite surgery (total abdo-
minal hysterectomy with bilateral salpingo-oophorectomy) were followed in the Gynecologic Endocrino-
logy and Menopause clinics. Patients were classified into 4 groups according to HRT regimens, i.e. control
(no HRT, n = 17), estrogen only (ERT, n =50), cyclic estrogen/progestin regimen (cyclic E/P, n =
16), and continuous combined estrogen/progestin (ccE/P, n
=
24). 12 patients who received more than
one regimen and 4 patients who received less than 6 months of HRT were excluded from the study.
The information was obtained from the medical records.
Results : Mean age at surgery of all patients was 38.9 years old. Mean duration of HRT was
41.2 months. There was no difference in age at surgery or duration of follow-up in each group. There
was 1 (2%) case of recurrent endometriosis and 3 (6%) cases of recurrent symptoms in the estrogen
only group; none of them required additional surgical treatment. Malignant transformation was not
found.
Conclusions : Although the present series is small, it seems that HRT is safe for postmeno-
pausal women with underlying endometriosis. Recurrence of endometriosis has rarely been a problem
with HRT, especially in those who received the combination of estrogen and progestin regimens.
Key word : Surgical Menopause, Endometriosis, HRT
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