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Original ArticleOpen Access
Water and Sodium Disorders in Children Undergoing Surgical Treatment of Brain Tumors
Hiranrat P 
,
Katavetin MP ,
Supornsilchai V ,
Wacharasindhu S ,
S
,
Katavetin MP ,
Supornsilchai V ,
Wacharasindhu S ,
S Background : Many children with brain tumors have abnormalities in water and sodium
homeostasis, such as diabetes insipidus (Dl), the syndrome of inappropriate antidiuretic hormone
secretion (SIADH) and cerebral salt wasting syndrome (CSW), either pre-operatively or post-opera-
tively. But little data have been published on the incidence, time of onset and clinical course of water
and sodium disorders in children with brain tumors.
Objectives : To characterize the water and sodium disorders in children undergoing surgical
treatment for brain tumors
Patients and Method : The medical records of children with brain tumors admitted for sur-
gery at King Chulalongkom Memorial Hospital from January 1997 to December 2002 were retrospec-
tively reviewed.
Results: There were 79 patients, 46 males and 33 females included in this study. Water and
sodium disorders occurred in 36 patients (45.57%), 23 patients had DI, 12 patients had SIADH and 1
patient had cerebral salt wasting syndrome (CSW). Nine of the 36 patients had pre-operative onset of
water and sodium disorders (8 DI and 1 SIADH). The development of DI and SIADH was associated
with the location of the brain tumors. Patients with sellar and suprasellar tumors had the highest inci-
dence of DI (75.86% ). Patients with tumors of the cerebral hemispheres had the highest incidence of
SIADH (44.44%). Onset of post-operative DI ranged from 2 to 19 hours (mean 9.68 hours) and most
patients developed SIADH within 24 hours post-operatively.
Vol. 86 Suppl 2
WATER
&
SODIUM DISORDERS IN CHILDREN WITH BRAIN TUMORS
S153
Conclusions : DI and SIADH are common problems in children with brain tumors, especially
after surgical treatment and the onset usually occurs within 24 hours after surgery. Patients with sellar
and suprasellar tumors are more likely to have DI, patients with tumors of cerebral hemispheres and
posterior fossa tumors are more likely to have SIADH.
Key word : Diabetes Insipidus, Inappropriate Antidiuretic Homone Secretion, Cerebral Salt Wasting,
Brain Tumor
homeostasis, such as diabetes insipidus (Dl), the syndrome of inappropriate antidiuretic hormone
secretion (SIADH) and cerebral salt wasting syndrome (CSW), either pre-operatively or post-opera-
tively. But little data have been published on the incidence, time of onset and clinical course of water
and sodium disorders in children with brain tumors.
Objectives : To characterize the water and sodium disorders in children undergoing surgical
treatment for brain tumors
Patients and Method : The medical records of children with brain tumors admitted for sur-
gery at King Chulalongkom Memorial Hospital from January 1997 to December 2002 were retrospec-
tively reviewed.
Results: There were 79 patients, 46 males and 33 females included in this study. Water and
sodium disorders occurred in 36 patients (45.57%), 23 patients had DI, 12 patients had SIADH and 1
patient had cerebral salt wasting syndrome (CSW). Nine of the 36 patients had pre-operative onset of
water and sodium disorders (8 DI and 1 SIADH). The development of DI and SIADH was associated
with the location of the brain tumors. Patients with sellar and suprasellar tumors had the highest inci-
dence of DI (75.86% ). Patients with tumors of the cerebral hemispheres had the highest incidence of
SIADH (44.44%). Onset of post-operative DI ranged from 2 to 19 hours (mean 9.68 hours) and most
patients developed SIADH within 24 hours post-operatively.
Vol. 86 Suppl 2
WATER
&
SODIUM DISORDERS IN CHILDREN WITH BRAIN TUMORS
S153
Conclusions : DI and SIADH are common problems in children with brain tumors, especially
after surgical treatment and the onset usually occurs within 24 hours after surgery. Patients with sellar
and suprasellar tumors are more likely to have DI, patients with tumors of cerebral hemispheres and
posterior fossa tumors are more likely to have SIADH.
Key word : Diabetes Insipidus, Inappropriate Antidiuretic Homone Secretion, Cerebral Salt Wasting,
Brain Tumor
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