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Original ArticleOpen Access
Serological analysis of Human Leukocyte Antigens-A and -B Antigens in Thai Patients with Nasopharyngeal Carcinoma
Pimtanothai N 
,
MSc OK ,
Charoenwongse P
,
MSc OK ,
Charoenwongse P NA TTIY A PIMT ANOTHAI, MD, PhD*,
ORA TAl KANGWANSHIRATADA, MSc*,
PREEY A CHIT CHAROENWONGSE, MD*
Objective: To study the distribution of human leukocyte antigens (HLA) -A and -B antigens
by standard microlymphocytotoxicity assay in Thai nasopharyngeal carcinoma (NPC) patients com-
pared to normal controls in order to identify the alleles associated with NPC in Thailand
Design: Retrospective-Analytical study
Subjects : Fifty-three unrelated Thai patients with histologically confirmed NPC diagnosed
at King Chulalongkom Memorial Hospital and 70 healthy unrelated Thai individuals served as con-
trols
Method : Lymphocyte separation and HLA typing were performed from freshly drawn blood
by standard microlymphocytotoxicity assay. The significance of differences between the two groups
was analyzed by the chi-square test
Results: HLA-A2 was observed at a greater frequency in patients being found in 31/53 (58%)
NPC patients compared to 27170 (38%) controls (p
=
0.02). An increase in HLA-B46 was also demon-
strated. HLA-B46 was present in 16/53 (30%) NPC patients but was observed in 10170 (14%) in con-
trols (p
=
0.03).
Conclusions : This study reported two susceptible, HLA-A2 and HLA-B46 antigens, for
NPC in a Thai population.
Key word : Nasopharyngeal Carcinoma, HLA-A, HLA-B
ORA TAl KANGWANSHIRATADA, MSc*,
PREEY A CHIT CHAROENWONGSE, MD*
Objective: To study the distribution of human leukocyte antigens (HLA) -A and -B antigens
by standard microlymphocytotoxicity assay in Thai nasopharyngeal carcinoma (NPC) patients com-
pared to normal controls in order to identify the alleles associated with NPC in Thailand
Design: Retrospective-Analytical study
Subjects : Fifty-three unrelated Thai patients with histologically confirmed NPC diagnosed
at King Chulalongkom Memorial Hospital and 70 healthy unrelated Thai individuals served as con-
trols
Method : Lymphocyte separation and HLA typing were performed from freshly drawn blood
by standard microlymphocytotoxicity assay. The significance of differences between the two groups
was analyzed by the chi-square test
Results: HLA-A2 was observed at a greater frequency in patients being found in 31/53 (58%)
NPC patients compared to 27170 (38%) controls (p
=
0.02). An increase in HLA-B46 was also demon-
strated. HLA-B46 was present in 16/53 (30%) NPC patients but was observed in 10170 (14%) in con-
trols (p
=
0.03).
Conclusions : This study reported two susceptible, HLA-A2 and HLA-B46 antigens, for
NPC in a Thai population.
Key word : Nasopharyngeal Carcinoma, HLA-A, HLA-B
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