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Original ArticleOpen Access
Efficacy of Albendazole Against Early and Late Stage of Trichinella spiralis Infection in Mice
Siriyasatien P 
,
Yingyourd P ,
Nuchprayoon S
,
Yingyourd P ,
Nuchprayoon S Efficacy of albendazole against early and late stage of
Trichinella spiralis
infection in mice
was determined. To determine the efficacy of albendazole against the early stage (enteral phase) of
trichinosis, mice experimentally infected with
T. spiralis
were treated with albendazole 20 mg/kg at
7 days post infection for 15 days. Larvae were recovered from the infected mice 7 days after the treat-
ment. The reduction rate of the larvae was 100 per cent. Efficacy of albendazole against the late stage
{parenteral phase) of infection was determined at 30 days post infection. Mice were treated with
albendazole at 20 mglkg for 30 days. Larvae were recovered from the infected mice 7 days after the
treatment. The reduction rate of the larvae was 71 per cent compared to the control group. In con-
clusion, albendazole was more effective in the early stage of infection than the late stage, the reduction
was 100 per cent and 71 per cent with respect to the control group respectively.
Key word
:
Trichinella spiralis,
Trichinosis, Albendazole
Trichinella spiralis
infection in mice
was determined. To determine the efficacy of albendazole against the early stage (enteral phase) of
trichinosis, mice experimentally infected with
T. spiralis
were treated with albendazole 20 mg/kg at
7 days post infection for 15 days. Larvae were recovered from the infected mice 7 days after the treat-
ment. The reduction rate of the larvae was 100 per cent. Efficacy of albendazole against the late stage
{parenteral phase) of infection was determined at 30 days post infection. Mice were treated with
albendazole at 20 mglkg for 30 days. Larvae were recovered from the infected mice 7 days after the
treatment. The reduction rate of the larvae was 71 per cent compared to the control group. In con-
clusion, albendazole was more effective in the early stage of infection than the late stage, the reduction
was 100 per cent and 71 per cent with respect to the control group respectively.
Key word
:
Trichinella spiralis,
Trichinosis, Albendazole
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