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Original ArticleOpen Access
Childhood Helicobacter pylori Infection, Clinical Presentations, Endoscopic, Histologic Features and Results of Treatment
Vithayasai N 
Objective
:To study childhood
Helicobacter pylori
infection concerning the clinical presen-
tations, endoscopic, histologic features and results of treatment.
Material and Method
:A retrospective study conducted at the Gastroenterology and Nutri-
tion Unit, Queen Sirikit National Institute of Child Health (QSNICH) was done from January 1993 to
December 2002. All patients presented with recurrent abdominal pain, upper GI bleeding (non-variceal
bleeding) chronic vomiting and dyspeptic symptoms who underwent upper GI endoscopy were included
in this study. Positive urease test verified by biopsied specimens from the gastric antrum and body and/
or finding the organisms from the specimens were the criteria for diagnosis of
H. pylori
infection. Cli-
nical presentations, endoscopic, histologic features and results of treatment in
H.
pylori
infected cases
were described.
Result
: A total of 144 patients who underwent upper GI endoscopy were included in the
study. 22 out of 144 cases proved to be infected by
H.
pylori.
Ages ranged from 2.6 to 14 years (mean
age 9 years). The male/female ratio was 1 : 1.2. Vomiting and epigastric pain were the leading symp-
toms. Endoscopic findings were divided into inflammation in the stomach 12 cases, both stomach and
duodenum 6 cases and duodenal ulcer 4 cases. Nodular hyperplasia of gastric antrum was found in 8
out of 22 cases. Histologic evidence of chronic gastritis was present in 12 cases, chronic gastroduo-
denitis 6 cases and chronic duodenitis in duodenal ulcer cases. Treatment regimen consisted of one
H
2
blocker (ranitidine) initially which was changed to omeprazole in 2001 combined with 2 antibiotics
(amoxycillin and metronidazole) for 14 days.
Conclusion
: This study group represented middle and low income groups from around
Bangkok and many parts ofThai1and. The prevalence of
H.
pylori
infection in the present study was 15.3
per cent which reflects that
H.
pylori
infection is a common health problem in Thailand. However,
because this was only a descriptive study, the authors cannot specify the association between symp-
toms, endoscopic findings, histologic features and disease.
Key word
:
Helicobacter pylori,
Childhood
:To study childhood
Helicobacter pylori
infection concerning the clinical presen-
tations, endoscopic, histologic features and results of treatment.
Material and Method
:A retrospective study conducted at the Gastroenterology and Nutri-
tion Unit, Queen Sirikit National Institute of Child Health (QSNICH) was done from January 1993 to
December 2002. All patients presented with recurrent abdominal pain, upper GI bleeding (non-variceal
bleeding) chronic vomiting and dyspeptic symptoms who underwent upper GI endoscopy were included
in this study. Positive urease test verified by biopsied specimens from the gastric antrum and body and/
or finding the organisms from the specimens were the criteria for diagnosis of
H. pylori
infection. Cli-
nical presentations, endoscopic, histologic features and results of treatment in
H.
pylori
infected cases
were described.
Result
: A total of 144 patients who underwent upper GI endoscopy were included in the
study. 22 out of 144 cases proved to be infected by
H.
pylori.
Ages ranged from 2.6 to 14 years (mean
age 9 years). The male/female ratio was 1 : 1.2. Vomiting and epigastric pain were the leading symp-
toms. Endoscopic findings were divided into inflammation in the stomach 12 cases, both stomach and
duodenum 6 cases and duodenal ulcer 4 cases. Nodular hyperplasia of gastric antrum was found in 8
out of 22 cases. Histologic evidence of chronic gastritis was present in 12 cases, chronic gastroduo-
denitis 6 cases and chronic duodenitis in duodenal ulcer cases. Treatment regimen consisted of one
H
2
blocker (ranitidine) initially which was changed to omeprazole in 2001 combined with 2 antibiotics
(amoxycillin and metronidazole) for 14 days.
Conclusion
: This study group represented middle and low income groups from around
Bangkok and many parts ofThai1and. The prevalence of
H.
pylori
infection in the present study was 15.3
per cent which reflects that
H.
pylori
infection is a common health problem in Thailand. However,
because this was only a descriptive study, the authors cannot specify the association between symp-
toms, endoscopic findings, histologic features and disease.
Key word
:
Helicobacter pylori,
Childhood
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