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Original ArticleOpen Access
Immunobullous Diseases in Thai Children : Report of 24 Cases
Singalavamja S 
,
Limpongsanurak W
,
Limpongsanurak W SRISUPALAK SIN GALA VANUA, MD*,
WANIDA LIMPONGSANURAK, MD*
Background : Acquired immunobullous diseases in children are very rare and difficult to
distinguish clinically.
Objective : To study the clinical manifestations, immunopathologic features, treatment and
outcome of immunobullous diseases in Thai children.
Material and Method : The authors reviewed 24 cases of immunobullous diseases in
children under 18 years at Queen Sirikit National Institute of Child Health from 1983 to 2000. Diagno-
sis of all cases was made by clinical presentations of chronic blistering diseases and confirmed by
histopathology and immunofluorescent studies.
Results :There were 18 cases of chronic bullous diseases of childhood (CBDC), 4 cases of
bullous pemphigoid (BP) and 2 cases of pemphigus vulgaris (PV). The mean age of onset of CBDC
and BP were 4 years and 2 years respectively. There was an equal male to female ratio in both CBDC
and BP. Both cases of pemphigus (neonate and 4 years old) were female. Most CBDC patients (18
cases) responded well to dapsone therapy although 2 cases had to be treated with prednisolone
simultaneously. All cases with BP were treated successfully with prednisolone and dapsone. Neonatal
pemphigus was treated symptomatically without steroid therapy. The second case of oral pemphigus
was controlled with low dose prednisolone.
Conclusion : Immunobullous diseases are very rare in children. All patients improved with
corticosteroid and/or dapsone therapy.
Key word : Immunobullous, Children
WANIDA LIMPONGSANURAK, MD*
Background : Acquired immunobullous diseases in children are very rare and difficult to
distinguish clinically.
Objective : To study the clinical manifestations, immunopathologic features, treatment and
outcome of immunobullous diseases in Thai children.
Material and Method : The authors reviewed 24 cases of immunobullous diseases in
children under 18 years at Queen Sirikit National Institute of Child Health from 1983 to 2000. Diagno-
sis of all cases was made by clinical presentations of chronic blistering diseases and confirmed by
histopathology and immunofluorescent studies.
Results :There were 18 cases of chronic bullous diseases of childhood (CBDC), 4 cases of
bullous pemphigoid (BP) and 2 cases of pemphigus vulgaris (PV). The mean age of onset of CBDC
and BP were 4 years and 2 years respectively. There was an equal male to female ratio in both CBDC
and BP. Both cases of pemphigus (neonate and 4 years old) were female. Most CBDC patients (18
cases) responded well to dapsone therapy although 2 cases had to be treated with prednisolone
simultaneously. All cases with BP were treated successfully with prednisolone and dapsone. Neonatal
pemphigus was treated symptomatically without steroid therapy. The second case of oral pemphigus
was controlled with low dose prednisolone.
Conclusion : Immunobullous diseases are very rare in children. All patients improved with
corticosteroid and/or dapsone therapy.
Key word : Immunobullous, Children
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