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Case ReportOpen Access
Intra-Articular Injection of Deproteinized Hemodialysate in Osteoarthritis ofthe Knee : A Case-Series
Kuptniratsaikul V 
,
S
,
S VILAI KUPTNIRA TSAIKUL, MD*,
SOMSAK KUPTNIRA TSAIKUL, MD**
Objective : To report the efficacy of intra-articular injection of deproteinized hemodialysate
including its side effects in a case-series of knee osteoarthritic (OA) patients.
Material and Method : Intra-articular injection of deproteinized hemodialysate was per-
formed in 17 subjects (3 male and 14 female) with primary knee OA. Their average age was 63 years
(min, max= 50,80 yrs). The X-ray appearance was grade II-III according to Kellgren-Lawrence criteria.
Measurements: 100 mm visual analogue scale (VAS) and any side effects.
Results : The mean (95% CI) of the VAS before and after injection were 70.0 (59.9-80.1) and
42.7 (31.2-54.2) respectively, with a p-value of< 0.001. The mean difference in pain score was 27.35
(95% CI = 17.0-37.7). The symptoms of knee pain resolved in an average of 4.8 (2.9) days (min, max =
1, 10). No side effects were found.
Conclusion : Intra-articular injection of deproteinized hemodialysate is effective and safe.
However, a further controlled trial with an adequate sample size should be performed to confirm the
efficacy as well as to detect any adverse effects of this drug.
Key word : Intra-Articular Injection, Deproteinized Hemodialysate, Knee Osteoarthritis, Case-Series
SOMSAK KUPTNIRA TSAIKUL, MD**
Objective : To report the efficacy of intra-articular injection of deproteinized hemodialysate
including its side effects in a case-series of knee osteoarthritic (OA) patients.
Material and Method : Intra-articular injection of deproteinized hemodialysate was per-
formed in 17 subjects (3 male and 14 female) with primary knee OA. Their average age was 63 years
(min, max= 50,80 yrs). The X-ray appearance was grade II-III according to Kellgren-Lawrence criteria.
Measurements: 100 mm visual analogue scale (VAS) and any side effects.
Results : The mean (95% CI) of the VAS before and after injection were 70.0 (59.9-80.1) and
42.7 (31.2-54.2) respectively, with a p-value of< 0.001. The mean difference in pain score was 27.35
(95% CI = 17.0-37.7). The symptoms of knee pain resolved in an average of 4.8 (2.9) days (min, max =
1, 10). No side effects were found.
Conclusion : Intra-articular injection of deproteinized hemodialysate is effective and safe.
However, a further controlled trial with an adequate sample size should be performed to confirm the
efficacy as well as to detect any adverse effects of this drug.
Key word : Intra-Articular Injection, Deproteinized Hemodialysate, Knee Osteoarthritis, Case-Series
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